E7019
Exendin-3
≥97%
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About This Item
Empirical Formula (Hill Notation):
C184H282N50O61S
CAS Number:
Molecular Weight:
4202.57
UNSPSC Code:
51111800
MDL number:
General description
Exendin-3 is a pancreatic secretagogue, which is a member of the glucagon family. It is found in the venom of Heloderma horridurn, which is a Gila monster lizard. It has a molecular mass of 4200Da and is composed of 39 amino acids. 12 amino-acids region in its N-terminal is highly homologous to secretin. Its C-terminal contains an amide group.
Application
Exendin-3 has been used to assess its effect in glucagon receptor knockout mice (Gcgr-/-) and wild-type mice, on glucose-stimulated insulin secretion.
Other Notes
Originally isolated from Heloderma horridum (Gila monster lizard) venom.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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J Eng et al.
The Journal of biological chemistry, 265(33), 20259-20262 (1990-11-25)
An amino-terminal histidyl structure (His1) is characteristic of most peptides in the glucagon superfamily. An assay for His1 peptides performed by amino-terminal amino acid sequencing was used to screen venom from the Gila monster lizard, Heloderma horridum. Two His1 peptides
Actions of Helodermatidae venom peptides and mammalian glucagon-like peptides on gastric chief cells.
Rai, A., et al.
The American Journal of Physiology, 265 (1993)
Bioactive peptides from lizard venoms.
J P Raufman
Regulatory peptides, 61(1), 1-18 (1996-01-16)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| E7019-.1MG | 04061832820286 |