E7649
Endothall
Synonym(s):
7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C8H10O5
CAS Number:
Molecular Weight:
186.16
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
205-660-5
MDL number:
SMILES string
OC(=O)C1[C@@H]2CC[C@@H](O2)C1C(O)=O
Gene Information
Biochem/physiol Actions
Potent inhibitor of phosphatase 2A, IC50 = 90 nM
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Acute Tox. 4 Dermal - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 1
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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B Szöör et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 112(3), 515-522 (1995-11-01)
The catalytic subunit of protein phosphatase 2A (PP2Ac) was purified from Neurospora crassa extract by (NH4)2SO4-ethanol precipitation followed by DEAE-Sephacel, heparin-Sepharose, and MonoQ chromatography steps about 900-fold to a specific activity of 1200 U/g with a 2% yield. The apparent
Rainer Schobert et al.
Bioorganic & medicinal chemistry, 16(18), 8592-8597 (2008-08-22)
A simplified procedure for the isolation of gram quantities of illudin M from culture broths of basidiomycete Omphalotus olearius is described. Esters of illudin M with docosahexaenoic acid, chlorambucil, demethylcantharidinic acid (endothall) and 2,2'-bipyridyl-5,5'-dicarboxylic acid were synthesised and tested for
Bertrand Faurie et al.
Journal of plant physiology, 166(17), 1863-1877 (2009-07-28)
Perception of elicitors triggers plant defense responses via various early signal transduction pathways. Methyl jasmonate (MeJA) stimulates defense responses in grapevine (Vitis vinifera). We investigated the involvement of various partners (calcium, ROS, reversible phosphorylation) in MeJA-induced responses by using a
F Erdödi et al.
The American journal of physiology, 269(5 Pt 1), C1176-C1184 (1995-11-01)
The objective of this study was to relate the toxicity of several cantharidin-derivative pesticides with their abilities to inhibit protein phosphatases-1 (PP1) and -2A (PP2A). Cantharidin (CA), endothall, and endothall thioanhydride (ETA) inhibited the activity of PP1 and PP2A, and
R Rakwal et al.
Gene, 263(1-2), 189-198 (2001-02-27)
The Bowman-Birk (BB) family of proteinase inhibitors (PI), initially reported from legume seeds, and thereafter also from wounded alfalfa and maize leaves appear to be regulated in similar ways as the extensively characterized PI I and PI II family from
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