E7653
Anti-S1P4, C-Terminal antibody produced in rabbit
~1 mg/mL, fractionated antiserum, buffered aqueous solution
Synonym(s):
Anti-EDG-6, Anti-Endothelial Cell Differentiation Gene 6
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
2
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
fractionated antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~45 kDa by SDS-PAGE
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... S1PR4(8698)
Immunogen
synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-6/S1P4 receptor.
Application
Anti-S1P4, C-Terminal antibody produced in rabbit is suitable for western blotting at a working concentration of 5 to 10 μg/ml using COS cells transfected with full length EDG-6.
Biochem/physiol Actions
Sphingosine-1-phosphate receptor 4 (S1PR4, EDG-6) is a human gene which encodes a G protein-coupled receptor and is identified as an orphan G-protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P). EDG-6 is a member of the endothelial differentiation gene (EDG) G protein-coupled receptor family. It is expressed in lymphoid, hematopoietic tissue and in the lung. EDG-6 acts as a high affinity receptor for SPP that couples to a G(i/o) protein leading to the activation of growth-related signaling pathways. It is one of the S1P or lysosphingolipid receptors that couples to phospholipase C-Ca2+ system through pertussis toxin-sensitive G-proteins.
Physical form
Supplied in phosphate buffered saline, pH 7.3, and 0.08% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
Regulatory Information
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Datasheet
Y Yamazaki et al.
Biochemical and biophysical research communications, 268(2), 583-589 (2000-02-19)
The endothelial differentiation gene-6 (Edg-6) was recently identified as an orphan G-protein-coupled receptor. Its predicted amino acid sequence is very close to Edg family of receptor proteins whose ligand is supposed to be lysophosphatidic acid (LPA) or lysosphingolipid such as
J R Van Brocklyn et al.
Blood, 95(8), 2624-2629 (2001-02-07)
EDG-6 is a recently cloned member of the endothelial differentiation gene (EDG) G protein-coupled receptor family that is expressed in lymphoid and hematopoietic tissue and in the lung. Homology of EDG-6 to the known sphingosine-1-phosphate (SPP) receptors EDG-1, EDG-3, and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| E7653-100UG | 04061838070906 |