E8527
EphA6/Fc Chimera from mouse
>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonym(s):
Ehk2, Hek12
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About This Item
MDL number:
UNSPSC Code:
51111800
biological source
mouse
recombinant
expressed in NSO cells
Assay
>90% (SDS-PAGE)
form
lyophilized powder
mol wt
monomer calculated mol wt 86 kDa
~100 kDa by SDS-PAGE (reducing)
storage condition
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
technique(s)
ligand binding assay: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Epha6(13840)
General description
EphA6 (ephrin receptor A6) is a receptor tyrosine kinase (RTK), which belongs to a 16 member family of ephrin receptors. This family is divided into two classes A and B. EphA5 belongs to EphA group, which contains 10 members. The ligands to this group of receptors are glycosylphosphatidylinositol (GPI)-anchored named ephrin-A1-A6. The members of this family have an ephrin-binding domain in its N-terminal globular domain, succeeded by a linker region rich in cysteine and two fibronectin type III repeats in the exoplasmic domain. Its cytoplasmic domain consists of a juxtamembrane region, a conserved tyrosine kinase domain, an α-helical C-terminal domain, and a PDZ domain-binding domian.
Biochem/physiol Actions
EphA6 (ephrin receptor A6) is a frequently mutated gene in colorectal cancer, in African-American population. In developing human retina, it is found in the ganglion cells of macula. It is involved in repellant-signaling, and hence, is involved in vascular patterning of retina, and also maintaining postnatal projection from ganglion cells of macula and fovea.
Member of the Eph receptor tyrosine kinase family shown to bind ephrin-A1, ephrin-A2, ephrin-A3, ephrin-A4, and ephrin-A5; involved in pattern formation and morphogenesis.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Analysis Note
The biological activity is measured by its ability to bind recombinant human ephrin-A3/Fc in an ELISA assay.
Other Notes
Extracellular domain of mouse EphA6 (amino acids 1-546) fused by means of a polypeptide linker to the Fc region of human IgG1 that is histidine-tagged at the C-terminus.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Kishore Guda et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(4), 1149-1154 (2015-01-15)
We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target
Xuelu Huan et al.
PloS one, 8(9), e74040-e74040 (2013-10-03)
The 16 EphA and EphB receptors represent the largest family of receptor tyrosine kinases, and their interactions with 9 ephrin-A and ephrin-B ligands initiate bidirectional signals controlling many physiological and pathological processes. Most interactions occur between receptor and ephrins of
Peter Kozulin et al.
Molecular vision, 15, 2649-2662 (2009-12-17)
Recently we identified high levels of expression of Eph-A6 in the macula of developing human retina and showed localization of Eph-A6 to ganglion cells (GC). In the present study we investigated the expression of some members of the ephrin family
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