E8531
Ethylenediaminetetra(methylenephosphonic acid)
Synonym(s):
EDTMP, EDTMPA
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About This Item
Empirical Formula (Hill Notation):
C6H20N2O12P4
CAS Number:
Molecular Weight:
436.12
UNSPSC Code:
12352200
EC Number:
215-851-5
InChI key
STNSYZSNIYTNMI-UHFFFAOYSA-N
InChI
1S/C6H20N2O12P4.H3N/c9-21(10,11)3-7(4-22(12,13)14)1-2-8(5-23(15,16)17)6-24(18,19)20;/h1-6H2,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);1H3
Application
Used as a complex with radioactive samarium as a radiopharmaceutical in cancer research. Corrosion inhibitor.
Biochem/physiol Actions
EDTMP is nitrogenous, polyphosphonic acid chelator that complexes with various metal ions.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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M Láznícek et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 45(9), 949-953 (1994-09-01)
The pharmacokinetics and elimination of EDTMP chelates with different radionuclides (99mTc, 111In and 153Sm) has been investigated in rats. The biodistribution of the complexes under study was similar and two main processes, namely bone uptake and the elimination of glomerular
M F Desrosiers et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 44(1-2), 459-463 (1993-01-01)
Therapeutic and palliative uses of bone-seeking radiopharmaceuticals are undergoing clinical trials for human subjects. Radiation dosimetry for these applications is based on the Medical Internal Radiation Dosimetry (MIRD) schema. An experimental method for dosimetry of bone tissue based on electron
J C Lattimer et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 31(8), 1316-1325 (1990-08-01)
Forty dogs with spontaneous skeletal neoplasia were treated with 153Sm-EDTMP (ethylenediaminetetramethylene phosphonic acid). Both primary and metastatic lesions were treated. Two treatment regimes, a single (37 MBq (1.0 mCi)/kg dose or two 37 MBq (1.0 mCi)/kg doses separated by 1
G J Beyer et al.
Nuclear medicine and biology, 24(5), 367-372 (1997-07-01)
High-resolution gamma spectroscopy was applied to measure simultaneously the biodistribution of carrier-free radionuclides of several lanthanides (141Ce, 145Sm, 149Gd, 167Tm) and 225Ac in tumor-bearing nude mice. Mixtures of the radiotracers were injected in solutions containing different concentrations of EDTMP (ethylenediaminetetramethylenephosphonic
Y Tanaka et al.
Shigaku = Odontology; journal of Nihon Dental College, 78(3), 575-591 (1990-10-01)
Dose dependent effects of EDTPO on morphology and mineralization of hard tissues as well as calcium (Ca), inorganic phosphorus (IP) and alkaline phosphatase (ALP) levels in serum were examined in growing rats. Five groups of male S.D. rats weighing 110-120g
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