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Merck
CN

E9163

Sigma-Aldrich

Cytochrome P450 2C19 human

recombinant, expressed in Saccharomyces cerevisiae

Synonym(s):

Cytochrome P450 Microsome Preparation human, Cerosomes

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About This Item

EC Number:
1.14.14.1 (BRENDA, IUBMB)
UNSPSC Code:
12352204

Key Documents

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biological source

human

Quality Level

200

recombinant

expressed in Saccharomyces cerevisiae

form

liquid

specific activity

≥1.0 units/pmol enzyme

secondary activity

≥100 units/mg protein (Reductase activity)

concentration

≥10 mg/mL protein (Bradford)
1 pmol/μL (P450)

UniProt accession no.

P20815

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CYP2C19(1577)

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General description

Microsome contents of CYP2C19 human and yeast CYP-reductase expressed in Saccharomyces cerevisiae.

Application

Recombinant cytochrome P450, isozyme 2C19, (CYP2C19) may be used in toxicity and drug metabolism research to identify its specificity and activity versus xenobiotic and endogenous compounds. Recombinant cytochrome P450, isozyme 2C19, may be used separately or as a component of a P450 isozyme panel to identify and characterize natural and synthetic selective inhibitors that affect the metabolism of toxic compounds or therapeutic drugs such as to facitinib, clopidogrel and voriconazole.

Physical form

50 mM Tris (pH 7.4), 1 mM EDTA, 20% glycerol

Other Notes

For more more information visit our drug metabolism resources for Cytochrome P450 microsome preparations.
P450 Activity: One unit will oxidize 1 picomole of diclofenac per minute at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBV6557
SLBN6424V
SLBG3127V
SLBG3126V

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