E9163
Cytochrome P450 2C19 human
recombinant, expressed in Saccharomyces cerevisiae
Synonym(s):
Cytochrome P450 Microsome Preparation human, Cerosomes
biological source
human
recombinant
expressed in Saccharomyces cerevisiae
form
liquid
specific activity
≥1.0 units/pmol enzyme
secondary activity
≥100 units/mg protein (Reductase activity)
concentration
≥10 mg/mL protein (Bradford), 1 pmol/μL (P450)
UniProt accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... CYP2C19(1577)
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General description
Microsome contents of CYP2C19 human and yeast CYP-reductase expressed in Saccharomyces cerevisiae.
Application
Recombinant cytochrome P450, isozyme 2C19, (CYP2C19) may be used in toxicity and drug metabolism research to identify its specificity and activity versus xenobiotic and endogenous compounds. Recombinant cytochrome P450, isozyme 2C19, may be used separately or as a component of a P450 isozyme panel to identify and characterize natural and synthetic selective inhibitors that affect the metabolism of toxic compounds or therapeutic drugs such as to facitinib, clopidogrel and voriconazole.
Physical form
50 mM Tris (pH 7.4), 1 mM EDTA, 20% glycerol
Other Notes
For more more information visit our drug metabolism resources for Cytochrome P450 microsome preparations.
P450 Activity: One unit will oxidize 1 picomole of diclofenac per minute at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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