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Merck
CN

E9384

[Cys(Acm)20,31]-Epidermal Growth Factor Fragment 20-31

≥97% (HPLC)

Synonym(s):

Cys(S-Acetamidomethyl)-Met-His-Ile-Glu-Ser-Leu-Asp-Ser-Tyr-Thr-Cys(Acm)

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About This Item

Empirical Formula (Hill Notation):
C63H98N16O23S3
CAS Number:
89991-90-2
Molecular Weight:
1543.74
UNSPSC Code:
12352200
PubChem Substance ID:
24894695
MDL number:
MFCD00133946

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Product Name

[Cys(Acm)20,31]-Epidermal Growth Factor Fragment 20-31, ≥97% (HPLC)

InChI

1S/C63H98N16O23S3/c1-9-31(4)50(78-58(96)43(20-36-22-65-27-66-36)73-54(92)40(16-17-103-8)69-52(90)38(64)25-104-28-67-33(6)83)61(99)70-39(14-15-48(86)87)53(91)75-45(23-80)59(97)71-41(18-30(2)3)55(93)74-44(21-49(88)89)56(94)76-46(24-81)60(98)72-42(19-35-10-12-37(85)13-11-35)57(95)79-51(32(5)82)62(100)77-47(63(101)102)26-105-29-68-34(7)84/h10-13,22,27,30-32,38-47,50-51,80-82,85H,9,14-21,23-26,28-29,64H2,1-8H3,(H,65,66)(H,67,83)(H,68,84)(H,69,90)(H,70,99)(H,71,97)(H,72,98)(H,73,92)(H,74,93)(H,75,91)(H,76,94)(H,77,100)(H,78,96)(H,79,95)(H,86,87)(H,88,89)(H,101,102)

SMILES string

CCC(C)C(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CCSC)NC(=O)C(N)CSCNC(C)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CO)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(C(C)O)C(=O)NC(CSCNC(C)=O)C(O)=O

InChI key

UEJSENUVDZJGAP-UHFFFAOYSA-N

assay

≥97% (HPLC)

UniProt accession no.

P01133

storage temp.

−20°C

Gene Information

human ... EGF(1950)

Biochem/physiol Actions

The fragment of mouse epidermal growth factor (EGF) that contains the receptor-binding region as well as the predominant EGF antigenic determinant. This fragment exhibits the biological activity of EGF in vitro.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
075K1362
126H02421
122H0869
122H08691
120K1179

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A Komoriya et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(5), 1351-1355 (1984-03-01)
A primary receptor-binding region of mouse epidermal growth factor (EGF) was identified by comparing the relative affinities of selected synthetic fragments with overlapping sequences in the EGF receptor-binding assay, using human foreskin fibroblasts. Only synthetic peptides containing the amino acid

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