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Merck
CN

E9777

Sigma-Aldrich

EphB6/Fc Chimera from mouse

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

Mep

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About This Item

MDL number:
MFCD01867529
UNSPSC Code:
51111800

Key Documents

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biological source

mouse

recombinant

expressed in NSO cells

Assay

>90% (SDS-PAGE)

form

lyophilized powder

mol wt

monomer calculated mol wt 87.3 kDa
 ~100 kDa by SDS-PAGE (reducing)

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

ligand binding assay: suitable

impurities

endotoxin, tested

UniProt accession no.

O08644

storage temp.

−20°C

Gene Information

mouse ... Ephb6(13848)

General description

EPHB6 (ephrin receptor B6) belongs to the largest receptor tyrosine kinase family called EPHB, and the members act as receptors for cell surface ephrin (eph) proteins. This protein is expressed on vascular smooth muscle cells (VSMC), lymphocytes and T-cells.

Biochem/physiol Actions

EPHB6 (ephrin receptor B6) is a member of EPHB receptor family, the members of which play a role in self-renewal of intestinal epithelium, development of uro-rectal tract, insulin secretion from pancreatic β cells, development, maintenance and repair of bone, regulation of hypoxia-induced red blood cell synthesis, glomerular filtration, clotting and homeostasis of vestibular endolymph fluid in the inner ear. EPHB6 receptor acts in co-ordination with sex hormones such as testosterone to control the contractility of vascular smooth muscle cells, and thus regulates the blood pressure.
Member of Eph receptor tyrosine kinase family shown to bind ephrin-B1 and ephrin-B2; involved in pattern formation and morphogenesis.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

The biological activity is measured by its ability to bind recombinant mouse ephrin-B2/Fc in an ELISA assay.

Other Notes

Extracellular domain of mouse EphB6 (amino acids 1-587) fused to the C-terminal 6X histidine-tagged Fc region of human IgG1 via a polypeptide linker.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
081K0150

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Hongyu Luo et al.
The Journal of biological chemistry, 287(9), 6819-6829 (2012-01-10)
Eph kinases constitute the largest receptor tyrosine kinase family, and their ligands, ephrins (Efns), are also cell surface molecules. Our study is the first to assess the role of Ephb6 in blood pressure (BP) regulation. We observed that EphB6 and

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