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Merck
CN

EPS001

HAT Activator, CTPB

A potent activator of HAT (histone acetyltransferase)

Synonym(s):

Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl, CTPB, CTPB (enzyme activator), CTPB (enzyme inhibitor), N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide

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About This Item

Empirical Formula (Hill Notation):
C31H43ClF3NO2
CAS Number:
586976-24-1
Molecular Weight:
554.13
UNSPSC Code:
12352200

Key Documents

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Product Name

HAT Activator, CTPB, A potent activator of HAT (histone acetyltransferase)

InChI key

OYBMVMAXKOGYDC-UHFFFAOYSA-N

InChI

1S/C31H43ClF3NO2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-18-24-19-17-20-28(38-4-2)29(24)30(37)36-25-21-22-27(32)26(23-25)31(33,34)35/h17,19-23H,3-16,18H2,1-2H3,(H,36,37)

assay

≥97% (H-NMR)

storage condition

desiccated
protect from light

color

white to off-white

solubility

DMSO: soluble

storage temp.

−20°C

General description

(N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide) or CTPB, which is a non-polar compound, has been shown to enhance the neurite growth and survival of neuronal cell lines.
A potent activator of p300 HAT (histone acetyltransferase), but not of PCAF (p300/CBP-associated factor) HAT activities.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Small molecule modulators of histone acetyltransferase p300
Karanam B et al.
The Journal of Biological Chemistry (2003)
A small molecule activator of p300/CBP histone acetyltransferase promotes survival and neurite growth in a cellular model of Parkinson?s disease
Shane VH et al.
Neurotoxicity Research, 30(3), 510-520 (2016)
Shufeng Li et al.
OncoTargets and therapy, 13, 12383-12395 (2020-12-11)
Cervical squamous cell carcinoma (CSCC) is responsible for 80-85% of cervical cancer. Cyclin B1 (CCNB1) represents a hub gene during the development of cervical cancer. However, the oncogenic role of CCNB1 in CSCC remains unclear. Our study aims to explore

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