F113
R(−)-Fenfluramine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H16F3N · HCl
CAS Number:
Molecular Weight:
267.72
UNSPSC Code:
12352116
PubChem Substance ID:
MDL number:
InChI
1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m1./s1
SMILES string
Cl.CCN[C@H](C)Cc1cccc(c1)C(F)(F)F
InChI key
ZXKXJHAOUFHNAS-SBSPUUFOSA-N
drug control
USDEA Schedule IV
Biochem/physiol Actions
Less active enantiomer
Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
监管及禁止进口产品
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Recent studies in the clinical pharmacology of anorectic drugs.
Silverstone, et al.
Recent Adv. Obes. Res., 5, 285-285 (1986)
Re: Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
Nicolas Deltour et al.
Pharmacoepidemiology and drug safety, 21(6), 584-585 (2012-04-21)
Enhanced behavioral response to serotonin-related agonists in postweaning protein malnourished mice.
Shoko Sato et al.
Biological & pharmaceutical bulletin, 35(10), 1697-1702 (2012-08-02)
We investigated whether postweaning protein malnutrition (PM) affects serotonergic systems. Mice were fed a PM diet or normal protein (control) diet from weaning (21 d of age). Twenty days later, we tested for behavioral effects of the selective serotonin (5-HT)(1A)
Benfluorex-induced cardiac valve injury.
Jean Acar
Pharmacoepidemiology and drug safety, 21(11), 1243-1244 (2012-10-31)
Laurent Savale et al.
The European respiratory journal, 40(5), 1164-1172 (2012-04-24)
Benfluorex was marketed in France until 2009, despite its similar pharmacological properties with fenfluramine and its derivatives known to be a cause of pulmonary arterial hypertension (PAH). The aim of this study is to report clinical and haemodynamic characteristics for
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