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Merck
CN

F2552

Formestane

solid

Synonym(s):

4-Hydroxyandrost-4-ene-3,17-dione, CGP-32349

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About This Item

Empirical Formula (Hill Notation):
C19H26O3
CAS Number:
566-48-3
Molecular Weight:
302.41
NACRES:
NA.25
PubChem Substance ID:
24894827
UNSPSC Code:
12352204
MDL number:
MFCD00057814

Key Documents

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Product Name

Formestane, solid

InChI key

OSVMTWJCGUFAOD-KZQROQTASA-N

SMILES string

C[C@]12CC[C@H]3[C@@H](CCC4=C(O)C(=O)CC[C@]34C)[C@@H]1CCC2=O

InChI

1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

chloroform: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

application(s)

forensics and toxicology
veterinary

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... CYP19A1(1588)

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Related Categories

Biochem/physiol Actions

Aromatase inhibitor used as an anti-cancer agent against estrogen-dependent tumors.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCS2320
MKCN7345
MKCF5599
MKCC3385
MKBX1177V

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Jie Wang et al.
Frontiers in systems neuroscience, 14, 546531-546531 (2020-10-06)
In rodents, the period of increased vulnerability to the developmental effects of general anesthetics coincides with the period of age-specific organizing (masculinizing) effects of the major female sex hormone 17β-estradiol (E2) in the male brain and excitatory GABA type A
L R Wiseman et al.
Drugs, 45(1), 66-84 (1993-01-01)
Formestane (4-hydroxyandrostenedione) is an effective and competitive inhibitor of aromatase, the enzyme responsible for the conversion of androgens to estrone and estradiol. Significant reductions in plasma estradiol levels are observed following intramuscular administration of formestane to postmenopausal women with advanced
Lucía Martínez-Mota et al.
Pharmacology, biochemistry, and behavior, 88(3), 332-340 (2007-10-05)
In male rats, the antidepressant-like effect of fluoxetine (FLX) and desipramine (DMI) in the forced swimming test (FST) is reduced by orchidectomy and partially restored by testosterone (T). It is unknown if this modulation of T is produced by its
Adam T Cawley et al.
Rapid communications in mass spectrometry : RCM, 22(24), 4147-4157 (2008-11-26)
Studies have shown that the administration of androstenedione (ADIONE) significantly increases the urinary ratio of testosterone glucuronide to epitestosterone glucuronide (T/E) - measured by gas chromatography/mass spectrometry (GC/MS) - in subjects with a normal ( approximately 1) or naturally high
L R Wiseman et al.
Drugs & aging, 9(4), 292-306 (1996-10-01)
Formestane (4-hydroxyandrostenedione) is an aromatase inhibitor which significantly reduces plasma levels of estrogen and has shown antitumour activity in postmenopausal women with breast cancer. Objective response rates in heavily pretreated patients with advanced breast cancer generally range between 20 and
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