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F2929

6-Fluoromevalonate

Name: 6-Fluoromevalonate
Brand: SIGMA

≥90% (GC), Mevalonate-pyrophosphate decarboxylase inhibitor, viscous liquid

Synonym(s):

Tetrahydro-4-fluoromethyl-4-hydroxy-2H-pyran-2-one, ZR 3516

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About This Item

Empirical Formula (Hill Notation):

C₆H₉FO₃

CAS Number:

2822-77-7

Molecular Weight:

148.13

UNSPSC Code:

51111800

PubChem Substance ID:

24724480

NACRES:

NA.77

MDL number:

MFCD08276919

Assay:

≥90% (GC)

Form:

viscous liquid

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Properties

Product Name

6-Fluoromevalonate, ≥90% (GC), viscous liquid

Quality Segment

100

assay

≥90% (GC)

form

viscous liquid

color

yellow tint

solubility

DMSO: ≥3 mg/mL

storage temp.

2-8°C

SMILES string

OC1(CF)CCOC(=O)C1

InChI

1S/C6H9FO3/c7-4-6(9)1-2-10-5(8)3-6/h9H,1-4H2

InChI key

DPPMVKMESJJAJZ-UHFFFAOYSA-N

Description

Application

6-Fluoromevalonate has been used as a mevalonate pyrophosphate decarboxylase inhibitor:

to study the effect of mevalonate pathway inhibition on patient-derived brain tumor-initiating cells (BTICs) growth and self-renewal
to study its effect on induction of trained immunity by β-glucan in monocytes
to determine the effect of the mevalonate pathway (MVP) on ADP-ribosylation factor 6 (ARF6) activation

Biochem/physiol Actions

Mevalonate-pyrophosphate decarboxylase inhibitor

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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