F4129
Fibrinogen from human plasma
55-75% protein, ≥60% of protein is clottable
Synonym(s):
Factor I
biological source
human plasma
form
powder
quality
≥60% of protein is clottable
mol wt
α-chain 63.5 kDa
β-chain 56 kDa
γ chain 47 kDa (about 4% carbohydrate content)
soluble dimer 340 kDa
concentration
55-75% protein (biuret)
55-75% protein
solubility
0.9% NaCl: soluble 10 mg/mL
storage temp.
−20°C
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General description
Fibrinogen, or Factor I, is a blood protein that is involved in clotting and is converted to fibrin by thrombin. Fibrinogen has an approximate molecular weight of 340 kDa.
Application
Fibrinogen was used in velocity variation assessment of red blood cell aggregation using spectral domain Doppler optical coherence tomography. It was also used to study the nano-bio interaction between graphite oxide nanoparticles and human blood components.
Biochem/physiol Actions
Acute phase protein that is part of the coagulation cascade of proteins.
Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyses fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.
Features and Benefits
Source material has tested negative for HIV and HBsAg.
Physical form
Lyophilized powder containing ~15% sodium citrate and ~20% sodium chloride.
Analysis Note
Protein determined by biuret
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Nano-Bio Interaction between Graphite Oxide Nano Particles and Human Blood Components
Hyoung-Mi Kim, Kyoung-Min Kim, Kyunghong Lee, Yoon Suk Kim and Jae-Min Oh
European Journal of Organic Chemistry, 5343-5349 (2012)
[The number of bacteria and fungi in "da-shan-zha-wan" pills].
Y Zhou
Zhong yao tong bao (Beijing, China : 1981), 10(12), 27-28 (1985-12-01)
Sachie Hiratsuka et al.
EMBO molecular medicine, 10(7) (2018-06-23)
Primary tumours establish metastases by interfering with distinct organs. In pre-metastatic organs, a tumour-friendly microenvironment supports metastatic cells and is prepared by many factors including tissue resident cells, bone marrow-derived cells and abundant fibrinogen depositions. However, other components are unclear.
Katarina Waldén et al.
The Annals of thoracic surgery, 97(4), 1199-1206 (2014-02-11)
Data from small selected patient populations suggest that the preoperative plasma concentration of fibrinogen influences postoperative blood loss and red blood cell transfusion after cardiac operations, but there are also conflicting reports. We assessed the importance of preoperative fibrinogen concentration
Keyvan Karkouti et al.
Anesthesia and analgesia, 117(1), 14-22 (2013-05-21)
Coagulopathy leading to excessive blood loss and large volume red cell transfusion is a frequent complication of cardiac surgery with cardiopulmonary bypass (CPB) that may be caused by low perioperative fibrinogen levels. We explored the relationship between post-CPB fibrinogen levels
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