F5929
Anti-FBG4 (FBXO17) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-F Box 4
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About This Item
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~31 kDa by calculation
species reactivity
mouse, human, rat
technique(s)
western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FBXO17(115290)
mouse ... Fbxo17(50760)
rat ... Fbxo17(292757)
Immunogen
peptide corresponding to the human FBG4 protein (amino acids 70-85).
Application
Anti-FBG4 (FBXO17) antibody is suitable for western blot at a dilution of 1:500-1:1,000.
Biochem/physiol Actions
F-box protein, is the critical component of conserved ubiquitin–protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box), and acts as a substrate recognition component of the ubiquitin ligase complex SCF (Skp-Cullin-F-box). It is expressed in human tissues including kidney, liver, brain and muscle tissues. It is associated with various critical biological processes such as in regulating the cell cycle, immune response, signaling cascades and developmental programs. The proteins have a bipartite structure and the core complex, whereas divergent protein-protein interaction motifs selectively bind their cognate substrates.
Physical form
Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Gennady P Ilyin et al.
Gene, 296(1-2), 11-20 (2002-10-18)
F-box proteins, a critical component of the evolutionary conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Here, we report the identification of full-length cDNAs encoding three novel human F-box
Laura Pontano Vaites et al.
Molecular and cellular biology, 31(22), 4513-4523 (2011-09-14)
Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complexes modulate the accumulation of key cell cycle regulatory proteins. Following the G(1)/S transition, SCF(Fbx4) targets cyclin D1 for proteasomal degradation, a critical event necessary for DNA replication fidelity. Deregulated cyclin D1 drives tumorigenesis, and
Margaret S Ho et al.
Journal of biomedical science, 13(2), 181-191 (2006-02-08)
The eukaryotic protein degradation pathway involves the ubiquitin (Ub) modification of substrates targeted for degradation by the 26S proteasome. The addition of Ub, a process called ubiquitination, is mediated by enzymes including the E3 Ub ligases which transfer the Ub
K L Craig et al.
Progress in biophysics and molecular biology, 72(3), 299-328 (1999-12-03)
The ubiquitin system of intracellular protein degradation controls the abundance of many critical regulatory proteins. Specificity in the ubiquitin system is determined largely at the level of substrate recognition, a step that is mediated by E3 ubiquitin ligases. Analysis of
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F5929-100UG | 04061837897061 |
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