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About This Item

Empirical Formula (Hill Notation):
C17H18F3N3O3
CAS Number:
79660-72-3
Molecular Weight:
369.34
MDL number:
MFCD00864880
UNSPSC Code:
51102829
PubChem Substance ID:
329799758
NACRES:
NA.85
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Assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

0.1 M NaOH: 10 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

Mode of action

DNA synthesis | interferes
enzyme | inhibits

storage temp.

−20°C

SMILES string

CN1CCN(CC1)c2c(F)cc3C(=O)C(=CN(CCF)c3c2F)C(O)=O

InChI

1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)

InChI key

XBJBPGROQZJDOJ-UHFFFAOYSA-N

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Application

Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It is used in pharmacokinetic studies and is used to study the treatment of intra-abdominal abscesses and travellers′ diarrhea.

Biochem/physiol Actions

Fleroxacin is a synthetic trifluorinated quinolone with antimicrobial activity against a variety of pathogens, including mycobacteria, mycoplasmas, chlamydiae, and legionellae. It strongly inhibits the DNA-supercoiling activity of DNA gyrase and DNA topoisomerase 2, which results in cell death.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCL5091
080M1481

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