F7176
Fibroblast Growth Factor-17 human
>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Synonym(s):
FGF-17
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About This Item
UNSPSC Code:
51111800
MDL number:
biological source
human
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE)
form
lyophilized powder
potency
10-30 ng/mL ED50
mol wt
calculated mol wt 22.6 kDa
storage condition
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... FGF17(8822)
General description
FGF17 (fibroblast growth factor 17) is a member of the secreted protein family called FGF. It is highly homologous to FGF8. Along with FGF18, it is a member of the FGF8 subfamily. It is expressed in midbrain-hindbrain (MHB) junction.
Biochem/physiol Actions
FGF-17 is a heparin binding growth factor preferentially expressed in embryonic brain. It is 60% identical to FGF-8 and 50% identical to FGF-18.
FGF17 (fibroblast growth factor 17) acts as a ligand for gonadotropin-releasing hormone (GnRH), which functions in neuron ontogeny. Mutations in this gene are also associated with congenital hypogonadotropic hypogonadism (CHH). Temporal and spatial gradients of this protein are responsible for the control of differentiation and proliferation of midline cerebrum.
Heparin binding growth factor preferentially expressed in embryonic brain.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in NR6R-3T3 fibroblasts.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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J Xu et al.
Mechanisms of development, 83(1-2), 165-178 (1999-06-25)
Fibroblast growth factors are essential molecules for development. Here we characterize Fgfl7, a new member of the fibroblast growth factor (FGF) family. The Fgfl7 gene maps to mouse chromosome 14 and is highly conserved between mouse and human (93% identity).
J Xu et al.
Development (Cambridge, England), 127(9), 1833-1843 (2000-04-06)
The midbrain-hindbrain (MHB) junction has the properties of an organizer that patterns the MHB region early in vertebrate development. Fgf8 is thought to mediate this organizer function. In addition to Fgf8, Fgf17 and Fgf18 are also expressed in the MHB
Hichem Miraoui et al.
American journal of human genetics, 92(5), 725-743 (2013-05-07)
Congenital hypogonadotropic hypogonadism (CHH) and its anosmia-associated form (Kallmann syndrome [KS]) are genetically heterogeneous. Among the >15 genes implicated in these conditions, mutations in FGF8 and FGFR1 account for ~12% of cases; notably, KAL1 and HS6ST1 are also involved in
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