F8883
2′-Fluoro-2′-deoxycytidine
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About This Item
Empirical Formula (Hill Notation):
C9H12FN3O4
CAS Number:
Molecular Weight:
245.21
UNSPSC Code:
12352204
MDL number:
storage temp.
2-8°C
SMILES string
NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2F
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Jeffrey J Bajramovic et al.
Antimicrobial agents and chemotherapy, 48(4), 1422-1425 (2004-03-30)
Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic
Lieven J Stuyver et al.
Antimicrobial agents and chemotherapy, 48(2), 651-654 (2004-01-27)
2'-Deoxy-2'-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5'-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due
Frank C Richardson et al.
Chemical research in toxicology, 15(7), 922-926 (2002-07-18)
Apatmers are synthesized using 2'-fluoropyrimdines in place of normal pyrmidines to stabilize them against enzymatic degradation, and thereby improve their therapeutic efficacy. Despite this stabilizing effect, the apatmers can still be degraded by nucleases in the blood. Primer template extension
S Helmling et al.
Nucleosides, nucleotides & nucleic acids, 22(5-8), 1035-1038 (2003-10-21)
Synthesis of 2'-fluoro-nucleosides from L-arabinose in order to perform the synthesis of 2'-fluoro-Spiegelmers binding to a neuropeptide.
Robert S Jansen et al.
Rapid communications in mass spectrometry : RCM, 23(19), 3040-3050 (2009-08-26)
A novel assay for the simultaneous quantification of the widely used anticancer agent 2',2'-difluorodeoxycytidine (gemcitabine; dFdC), its deaminated metabolite 2',2'-difluorodeoxyuridine (dFdU) and their mono-, di- and triphosphates (dFdCMP, dFdCDP, dFdCTP, dFdUMP, dFdUDP and dFdUTP) in peripheral blood mononuclear cells (PBMCs)
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