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Merck
CN

F9553

FTI-276 trifluoroacetate salt

≥95% (HPLC)

Synonym(s):

N-[4-[2-(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C21H27N3O3S2 ·C2HF3O2
CAS Number:
170006-72-1
Molecular Weight:
547.61
NACRES:
NA.77
PubChem Substance ID:
329799788
UNSPSC Code:
12352200
MDL number:
MFCD06409253

Key Documents

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InChI

1S/C21H27N3O3S2.C2HF3O2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14;3-2(4,5)1(6)7/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27);(H,6,7)/t15-,19+;/m1./s1

SMILES string

OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2ccccc2)C(O)=O

InChI key

IAVHISGQCODLHL-WSCVZUBPSA-N

assay

≥95% (HPLC)

form

film

storage condition

desiccated, under inert gas

color

off-white

solubility

H2O: >5 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

FTI-276 is a highly potent RasCAAX peptidomimetic.
FTI-276 is a highly potent RasCAAX peptidomimetic. FTI-276 antagonizes both H and K-Ras oncogenic signaling. It is an inhibitor of farnesyltransferase (Ftase) in vitro with an IC50 of 500 pM and is an anti-cancer agent.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
035M4609V
090M4636V
029K46171
029K4617
044K4618

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Michela Terlizzi et al.
Cells, 11(16) (2022-08-27)
Sphingosine-1-phosphate (S1P) is involved in inflammatory signaling/s associated with the development of respiratory disorders, including cancer. However, the underlying mechanism/s are still elusive. The aim of this study was to investigate the role of S1P on circulating blood cells obtained
Xue Chen et al.
eLife, 10 (2021-02-03)
A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by inactivating the isoprenylcysteine carboxylmethyltransferase (ICMT) gene stimulates proliferation of HGPS cells and improves survival of Zmpste24-deficient mice. However, we don't know
Manpreet Malhi et al.
Communications biology, 4(1), 1239-1239 (2021-10-31)
Respiratory syncytial virus (RSV) is a leading cause of severe respiratory tract infections in children. To uncover new antiviral therapies, we developed a live cell-based high content screening approach for rapid identification of RSV inhibitors and characterized five drug classes

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