G0267
Mini Gastrin I human
≥97% (HPLC)
Synonym(s):
HG-13
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About This Item
Empirical Formula (Hill Notation):
C74H99N15O26S
CAS Number:
Molecular Weight:
1646.73
UNSPSC Code:
12352200
MDL number:
SMILES string
CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
assay
≥97% (HPLC)
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... GAST(2520)
Biochem/physiol Actions
CCKB/gastrin receptor agonist. Corresponds to fragment 5-17 of human gastrin I. This form of gastrin has been isolated from tumor tissue.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Meltem Ocak et al.
Nuclear medicine and biology, 38(2), 171-179 (2011-02-15)
Lack of correlation between in vitro and in vivo stability is a general problem for the development of radiopeptides especially in the case of minigastrin derivatives for therapeutic applications. In this study, we compared the influence of experimental conditions on
Peter Laverman et al.
European journal of nuclear medicine and molecular imaging, 35(2), 386-392 (2007-10-16)
Radiolabelled cholecystokinin (CCK) and gastrin-derived peptides potentially can be used for peptide receptor radionuclide therapy (PRRT). Recently, a splice variant version of the CCK2R has been identified, designated CCK2i4svR. Constitutive expression of this receptor has been demonstrated in human colorectal
J C Galleyrand et al.
Peptides, 13(3), 519-525 (1992-05-01)
Binding to gastrin receptors and gastric acid secretion experiments were performed with gastrin derivatives modified at the C-terminal tetrapeptide amide from HG-13 sequence. 1. When the ultimate phenylalanine amide was replaced by a phenethylester or a phenetylamide moiety, the resulting
Martin Gotthardt et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 48(4), 596-601 (2007-04-03)
Nephrotoxicity due to renal reabsorption of radiolabeled peptides limits the tumor dose in peptide receptor radiotherapy (PRRT). Therefore, we evaluated the ability of several agents to inhibit the renal accumulation of different radiopeptides. Male Wistar rats (4 per group) were
Syed Ali-Raza Naqvi et al.
Pakistan journal of pharmaceutical sciences, 26(2), 299-305 (2013-03-05)
Radiolabeled neuropeptides are widely investigated to diagnose and therapy of tumors. These peptides get internalization after binding with particular receptors at the surface of cells and finally move to lysosome. Internalization into tumor cells helps in mapping the infected site.
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