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Merck
CN

G0416

Sigma-Aldrich

Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert C2′) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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About This Item

MDL number:
UNSPSC Code:
12352203
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

antigen 100 kDa

species reactivity

rat, mouse

technique(s)

immunoprecipitation (IP): 1:200
western blot: 1:1000 using rat and mouse brain homogenates and HEK 293 cells

UniProt accession no.

storage temp.

2-8°C

Gene Information

mouse ... Grin1(14810)
rat ... Grin1(24408)

Immunogen

synthetic peptide representing the sequence of the C2′ splice variant.

Application

Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert C2′) antibody is suitable for immunoprecipitation at a dilution of 1:200 and western blot at a dilution of 1:1000 using rat and mouse brain homogenates and HEK 293 cells.

Biochem/physiol Actions

NMDA receptors (NMDAR) are glutamate-gated ion channels. It is sensitive to N-methyl-D-aspartate (NMDA) and consists of several homologous subunits (NMDAR1). NMDAR is highly expressed in the central nervous system and involved in excitatory synaptic transmission as well as synaptic plasticity. The activity of NMDA receptors are modulated by glycine. It exhibits high calcium permeability and unique voltage-dependent sensitivity to magnesium. It has been reported that phosphorylated NMDA receptors may regulate their function and play a role in many forms of synaptic plasticity such as long-term potentiation.

Physical form

Lyophilized powder from 5 mM ammonium bicarbonate (some residual salt may be present)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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R S Zukin et al.
Trends in neurosciences, 18(7), 306-313 (1995-07-01)
Molecularly diverse forms of the NMDA-receptor subunit NRI are formed by alternative RNA splicing. Differential splicing of three exons generates as many as eight NRI splice variants, seven of which have been identified in cDNA libraries. The alternatively spliced exons
Tue G Banke et al.
Nature neuroscience, 6(2), 144-152 (2003-01-14)
N-methyl-D-aspartate (NMDA) receptors are highly expressed in the central nervous system and are involved in excitatory synaptic transmission as well as synaptic plasticity. Despite considerable structural and biophysical research, the mechanism behind activation of the NMDA receptor is still poorly
T Ishii et al.
The Journal of biological chemistry, 268(4), 2836-2843 (1993-02-05)
cDNA clones for four different N-methyl-D-aspartate (NMDA) receptor subunits (NMDAR2A-NMDAR2D) were isolated through polymerase chain reactions followed by molecular screening of a rat brain cDNA library. These subunits are only about 15% identical with the key subunit of the NMDA
W G Tingley et al.
Nature, 364(6432), 70-73 (1993-07-01)
The NMDA (N-methyl D-aspartate) receptors in the brain play a critical role in synaptic plasticity, synaptogenesis and excitotoxicity. Molecular cloning has demonstrated that NMDA receptors consist of several homologous subunits (NMDAR1, 2A-2D). A variety of studies have suggested that protein
K Moriyoshi et al.
Nature, 354(6348), 31-37 (1991-11-07)
A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant

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