G0419
GR 55562 dihydrobromide
>97% (HPLC), powder
Synonym(s):
3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrobromide
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About This Item
Empirical Formula (Hill Notation):
C23H25N3O2 · 2HBr
CAS Number:
Molecular Weight:
537.29
UNSPSC Code:
12352202
MDL number:
Assay:
>97% (HPLC)
Form:
powder
description
Store tightly sealed with desiccant.
assay
>97% (HPLC)
form
powder
color
light yellow
solubility
H2O: ~12 mg/mL (with mixing)
storage temp.
2-8°C
InChI
1S/C23H25N3O2.ClH/c1-26(2)15-3-4-19-16-20(7-10-22(19)27)23(28)25-21-8-5-17(6-9-21)18-11-13-24-14-12-18;/h5-14,16,27H,3-4,15H2,1-2H3,(H,25,28);1H
InChI key
NUDSRNNZTVHCKY-UHFFFAOYSA-N
Biochem/physiol Actions
5-HT1B/5-HT1D serotonin receptor antagonist
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Zheng-Ming Ding et al.
Psychopharmacology, 204(3), 381-390 (2009-01-24)
Previous studies indicated that ethanol could be self-infused into the posterior ventral tegmental area (p-VTA) and that activation of local serotonin-3 (5-HT(3)) receptors was involved. 5-HT(1B) and 5-HT(2A) receptors are involved in the effects of 5-HT and ethanol on VTA
Edmund Przegaliński et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 14(3), 217-225 (2004-04-02)
The present study was aimed at finding out whether 5-HT(1B) receptors located in the ventral tegmental area (VTA) played a role in the locomotor hyperactivity induced by a single dose of cocaine and in the sensitization evoked by repeated exposure
Iwona Papla et al.
Polish journal of pharmacology, 54(4), 351-357 (2003-01-14)
Previous research demonstrated that the mesoaccumbens dopamine (DA) pathway played a critical role in the behavioral effects of amphetamine in rodents. Nonetheless, recent findings have also indicated involvement of 5-hydroxytryptamine (5-HT, serotonin) transmission in these effects. In the present study