G0548
14-3-3 Gamma, histidine-tagged human
recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥90% (SDS-PAGE)
Synonym(s):
KCIP-1, Tyrosine 3-monooxygtenase/tryptophan 5-monooxygenase activation protein, gamma isoform, YWHAG
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About This Item
UNSPSC Code:
12352200
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
buffered aqueous glycerol solution
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
The 14-3-3 proteins are a multifunctional protein family comprising seven mammalian isoforms that interact with over two hundred different intracellular molecules including kinases, phosphatases, transcription factors, scaffold proteins, and DNA. 14-3-3 proteins are linked to many human diseases. The 14-3-3 γ isoform is abundantly expressed in the brain with increased levels in Alzheimer′s disease and Down′s syndrome. 14-3-3 γ is involved in cancerous processes including the stimulation of abnormal cell proliferation.
Physical form
Supplied as a 0.2 μm filtered solution in 50 mM Tris, pH 7.6, 1 mM EDTA, 1 mM DTT, and 20% glycerol (w/v).
Regulatory Information
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14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation.
Guri Tzivion et al.
The Journal of biological chemistry, 277(5), 3061-3064 (2001-11-16)
José M A Moreira et al.
Molecular & cellular proteomics : MCP, 7(7), 1225-1240 (2008-04-02)
The 14-3-3 proteins constitute a family of highly conserved and broadly expressed multifunctional polypeptides that are involved in a variety of important cellular processes that include cell cycle progression, growth, differentiation, and apoptosis. Although the exact cellular function(s) of 14-3-3
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