G116
Guanylin
>96%, solid
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About This Item
Empirical Formula (Hill Notation):
C60H90N16O22S4
CAS Number:
Molecular Weight:
1515.71
UNSPSC Code:
41106305
MDL number:
assay
>96%
form
solid
color
white
storage temp.
−20°C
Biochem/physiol Actions
Peptide isolated from rat intestine which activates intestinal guanylyl cyclase in a human colon carcinoma-derived cell line (T84); resembles heat-stable endotoxins produced by E. coli.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M G Currie et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(3), 947-951 (1992-02-01)
Intestinal guanylate cyclase mediates the action of the heat-stable enterotoxin to cause a decrease in intestinal fluid absorption and to increase chloride secretion, ultimately causing diarrhea. An endogenous ligand that acts on this guanylate cyclase has not previously been found.
R C Wiegand et al.
Biochemical and biophysical research communications, 185(3), 812-817 (1992-06-30)
Guanylin is a recently discovered endogenous activator of intestinal guanylate cyclase that was purified from intestinal tissue. Clones have been isolated which demonstrate that the guanylin peptide is contained within a 115 amino acid apparent preprohormone encoded by a 600