Skip to Content
Merck
CN

G1171

Gö 6976

≥98% (HPLC), powder

Synonym(s):

12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, Go 6976

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C24H18N4O
CAS Number:
136194-77-9
Molecular Weight:
378.43
UNSPSC Code:
12352200
PubChem Substance ID:
329799832
MDL number:
MFCD00236434

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Gö 6976, ≥98% (HPLC), powder

InChI

1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)

SMILES string

Cn1c2ccccc2c3c4C(=O)NCc4c5c6ccccc6n(CCC#N)c5c13

InChI key

VWVYILCFSYNJHF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: >5 mg/mL

storage temp.

−20°C

Looking for similar products? Visit Product Comparison Guide

Application

Gö 6976 has been used:
  • as an inhibitor of protein kinase C (PKC) in mammalian cell lines
  • as a PKCμ inhibitor in oocytes
  • as a PKC-α to test its effect on phosphorylation of protein kinase-B (Akt) and extracellular-signal-regulated kinase (ERK) levels

Biochem/physiol Actions

Go¨6976 also acts as an effective inhibitor of protein kinase C isoform (PKCμ) and abolishes phorbol ester mediated potentiation in oocytes. It inhibits PKC α and β selectively. Go-6976 may also inhibit S6-kinase 1.
Gö 6976 is an inhibitor of protein kinase C (PKC) specific for α (IC50=2.3 nM) and β1 (IC50=6.2 nM) isozymes.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
122M4710V
022M4702V
061M4721V
061M4702V
110M4710V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Hairuo Wen et al.
Journal of neurochemistry, 108(2), 331-340 (2008-12-03)
The potentiation of P2X(1) receptor currents by phorbol ester (PMA) treatment and stimulation of mGluR1alpha receptors was sensitive to inhibition of novel forms of protein kinase C. Potentiation was also reduced by co-expression of an amino terminal P2X(1) receptor minigene.
Katherine A Robinson et al.
PloS one, 9(10), e108963-e108963 (2014-10-21)
Chronic hyperglycemia induces insulin resistance by mechanisms that are incompletely understood. One model of hyperglycemia-induced insulin resistance involves chronic preincubation of adipocytes in the presence of high glucose and low insulin concentrations. We have previously shown that the mTOR complex
Shaon Naskar et al.
PloS one, 9(8), e104711-e104711 (2014-08-15)
A cardiac hypertrophy is defined as an increase in heart mass which may either be beneficial (physiological hypertrophy) or detrimental (pathological hypertrophy). This study was undertaken to establish the role of different protein kinase-C (PKC) isoforms in the regulation of
Hammou Oubrahim et al.
The Journal of biological chemistry, 288(4), 2805-2815 (2012-12-12)
Pasteurella multocida toxin (PMT) is a potent mitogen known to activate several signaling pathways via deamidation of a conserved glutamine residue in the α subunit of heterotrimeric G-proteins. However, the detailed mechanism behind mitogenic properties of PMT is unknown. Herein
Wei Cao et al.
Antioxidants & redox signaling, 18(1), 19-35 (2012-06-06)
Activation of intrarenal renin-angiotensin system (RAS) has a detrimental effect on the progression of chronic kidney diseases (CKDs), although the regulation of intrarenal RAS remains unclear. The aim of the present study was to evaluate the role of advanced oxidation
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service