G1274
HA-1004 hydrochloride
≥98% (HPLC), powder
Synonym(s):
N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H15N5O2S · HCl
CAS Number:
Molecular Weight:
329.81
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98% (HPLC)
form
powder
color
white
solubility
H2O: 10 mM
ethanol: 10 mg/mL
storage temp.
−20°C
SMILES string
Cl.NC(=N)NCCNS(=O)(=O)c1cccc2cnccc12
InChI
1S/C12H15N5O2S.ClH/c13-12(14)16-6-7-17-20(18,19)11-3-1-2-9-8-15-5-4-10(9)11;/h1-5,8,17H,6-7H2,(H4,13,14,16);1H
InChI key
GUGJQAFPKZZOIV-UHFFFAOYSA-N
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Biochem/physiol Actions
Shown to be an intracellular calcium antagonist. Reported to induce neurite formation.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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M R Crowley et al.
Journal of cardiovascular pharmacology, 23(5), 806-813 (1994-05-01)
HA1004, an isoquinolinesulfonamide and a cyclic nucleotide-dependent protein kinase inhibitor, is an intracellular calcium antagonist that produces vascular smooth muscle (VSM) relaxation in vitro. We studied the hemodynamic effects of intravenous (i.v.) infusions of HA1004 (0.1-2.0 mg/kg) in vivo in
H Tsushima et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 8(12), 1317-1328 (1998-01-07)
Erythropoietin (Epo) is a cytokine known to stimulate proliferation and differentiation of erythroid cells. However, recent gene disruption experiments demonstrated that Epo receptor signaling is not an obligatory step in erythroid differentiation. Here, we describe the role of Epo in
J C Leahy et al.
Neuroscience, 44(2), 361-370 (1991-01-01)
The effects of the isoquinolinesulfonamide protein kinase inhibitors 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) and N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA1004) on CA1 responses in hippocampal slices of the rat were examined to clarify their mode of action, and also to further define the role of Ca(2+) -dependent
S F Luo et al.
Cellular signalling, 9(2), 159-167 (1997-02-01)
The effects of increases in intracellular adenosine 3':5'-cyclic monophosphate (cyclic AMP) on bradykinin (BK)-induced generation of inositol phosphates (IPs) and Ca2+ mobilization were investigated in canine cultured tracheal smooth muscle cells (TSMCs). Pretreatment of TSMCs with either forskolin or dibutyryl
T Hiwasa et al.
Neuroscience letters, 238(3), 115-118 (1998-02-17)
The effects of various inhibitors on the glial cell line-derived neurotrophic factor (GDNF)-induced neurite formation in TGW human neuroblastoma cells were investigated. Treatment of cells with Ser/Thr protein kinase inhibitors such as staurosporine, H-7, H-8 and HA-1004, induced neurite formation
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