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About This Item
Empirical Formula (Hill Notation):
C6H11NO4
CAS Number:
Molecular Weight:
161.16
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
form
solid
optical activity
[α]23/D +23.2°, c = 0.73 in 6 M HCl(lit.)
color
white
solubility
H2O: >10 mg/mL
SMILES string
C[C@H](C[C@H](N)C(O)=O)C(O)=O
InChI
1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
InChI key
KRKRAOXTGDJWNI-DMTCNVIQSA-N
Gene Information
human ... GRIK1(2897), GRIK2(2898), SLC1A1(6505), SLC1A2(6506)
rat ... Gria1(50592), Grik1(29559), Grin2a(24409), Slc1a2(29482)
Application
(2S,4R)-4-Methylglutamic acid has been used as a kainate receptor (KAR) antagonist to test its effect on acetylcholine release in muscle cells.
Biochem/physiol Actions
(2S,4R)-4-Methylglutamic acid (SYM 2081) is a selective antagonist for the kainate receptor that elicits antihyperalgesic and antinociceptive functionality. It may be useful to treat mechanical allodynia associated with the cold-freeze injury model. SYM 2081 also mediates the suppression of glutamate release from injured C-fibers. It may also be involved in the attenuation of heat hyperalgesia in nerve injury models.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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