G1538
Gelsolin from human plasma
~90% (SDS-PAGE), lyophilized powder, 100-300 units/mg protein
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About This Item
UNSPSC Code:
12352204
MDL number:
General description
Human gelsolin (also known as brevin) is an actin severing protein found in mammalian cells and blood plasma. Gelsolins consist of a 730 amino acid core structure which contains six repeated domains. These six domains make up three distinct actin binding sites. The plasma enzyme contains an N-terminal extension of 25 amino acids that raises its molecular weight from 90 kD to 93 kD.
Application
Plasma gelsolin levels may be used to identify patients at risk for increased morbidity.
Biochem/physiol Actions
Gelsolin is an actin-binding protein that regulates the assembly and disassembly of actin filaments.
Gelsolin is an actin-severing protein found in mammalian cells and blood plasma. Exhibits tumor suppressor activity in several cancer cell lines and in nude mice.
Packaging
Package size based on protein content
Physical form
Lyophilized powder containing Tris buffer salts, pH 7.6, NaCl, DTT, and EGTA
Other Notes
One unit will reduce viscosity difference between actin solution and buffer by 50% in a 1 mL mixture containing 1-2 mg F-actin, 0.15 M KCl, 20 mM Tris, pH 7.6, 0.2 mM CaCl2, 0.2 mM ATP and 1 mM DTT at 28°C.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Po-Shun Lee et al.
Annals of surgery, 243(3), 399-403 (2006-02-24)
To examine the relationship between plasma gelsolin levels and mortality following surgery or trauma. Few simple predictive diagnostic tests are available to predict mortality following surgery or trauma. We hypothesize that plasma concentrations of gelsolin, a protein that responds to
Markus Ganter et al.
Molecular microbiology, 74(6), 1356-1367 (2009-08-18)
Summary Successful malaria transmission from the mosquito vector to the mammalian host depends crucially on active sporozoite motility. Sporozoite locomotion and host cell invasion are driven by the parasite's own actin/myosin motor. A unique feature of this motor machinery is
C A Vasconcellos et al.
Science (New York, N.Y.), 263(5149), 969-971 (1994-02-18)
Obstruction of airways by viscous sputum causes lung damage in patients with cystic fibrosis (CF). Sputum samples from CF patients were shown to contain filamentous actin. Human plasma gelsolin, a protein that severs actin filaments, rapidly decreased the viscosity of
Eun Young Park et al.
Bioscience reports, 32(4), 393-400 (2012-05-30)
The plasma level of LPA (lysophosphatidic acid) (200-600 nM) is well within the range that promotes proliferation and migration of vascular ECs (endothelial cells), yet vessels are quiescent and stable. In this report, we considered one explanation for this paradox:
R C Koya et al.
The Journal of biological chemistry, 275(20), 15343-15349 (2000-05-16)
Apoptotic cell death, characterized by chromatin condensation, nuclear fragmentation, cell membrane blebbing, and apoptotic body formation, is also accompanied by typical mitochondrial changes. The latter includes enhanced membrane permeability, fall in mitochondrial membrane potential (Deltapsi(m)) and release of cytochrome c
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