G1674
Gliadorphin-7
Synonym(s):
α/β-Gliadin (43-49), GD-7, gluteomorphin, Prolamin (43-49)
biological source
wheat (gluten)
form
lyophilized powder
color
white
solubility
water, double-distilled: soluble
storage temp.
−20°C
Amino Acid Sequence
H-Tyr-Pro-Gln-Pro-Gln-Pro-Phe-OH
General description
Gliadorphin-7 is a peptide corresponding to amino-acids 43-49 of gliadin, a component of the gluten protein. Gliadorphin-7 is an opoid peptide formed in the body by the digestion of the gliadin. Accumulation of this peptide was found in autism, schizophrenia and cealic disease possibly due to improper proteolysis.
Gliadorphin-7 is one of the seven most commonly known gluten exorphins (GEs), which is a peptide derived from gliadin. Gliadin is a component of gluten found in wheat. Gliadorphin-7 peptide is produced upon the digestion of wheat glutens, and has an opioid-like activity. It is composed of Tyr-Pro-Gln-Pro-Gln-Pro-Phe, Gd-7.
Biochem/physiol Actions
Gliadorphin-7 can reach regions in brain by diffusion circumventricular organs. Studies in rats show that gliadorphin-7 (GD-7) infusion results in high presence of this peptide in both geniculate nuclei (GN) and the alveus hippocampus.
Physical form
Lyophilized from 0.1% aqueous TFA
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Zhongjie Sun et al.
Peptides, 24(2), 321-323 (2003-04-02)
This paper discusses the effects of gliadorphin-7 (GD-7) infusion in rats and contrasts them with those of beta-casomorphin-7 (betaC-7). Both induce FLI in a dose related fashion. Very strong expression in both geniculate nuclei (GN) and the alveus hippocampus follow
Release of wheat gluten exorphins A5 and C5 during in vitro gastrointestinal digestion of bread and pasta and their absorption through an in vitro model of intestinal epithelium.
Stuknyte, M et al
Food Research International, 72, 208-214 (2015)
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