G1876
L-Glutamic acid γ-ethyl ester
Synonym(s):
L-Glutamic acid 5-ethyl ester
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About This Item
Linear Formula:
C2H5OCOCH2CH2CH(NH2)COOH
CAS Number:
Molecular Weight:
175.18
EC Number:
214-274-6
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
1725589
MDL number:
InChI
1S/C7H13NO4/c1-2-12-6(9)4-3-5(8)7(10)11/h5H,2-4,8H2,1H3,(H,10,11)/t5-/m0/s1
InChI key
XMQUEQJCYRFIQS-YFKPBYRVSA-N
SMILES string
CCOC(=O)CC[C@H](N)C(O)=O
application(s)
peptide synthesis
storage temp.
−20°C
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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V M Kozhanov et al.
Tsitologiia, 46(4), 326-336 (2004-09-07)
The role of group II metabotropic glutamate receptors (mGluRs) in modulation of inhibitory synaptic activity was studied by intracellular recording of motoneuron miniature inhibitory spontaneous postsynaptic potentials (mIPSPs) in isolated lumbar segments of the turtle spinal cord in the medium
Functional organization of presynaptic metabotropic glutamate receptors in vagal brainstem circuits.
Kirsteen N Browning et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(34), 8979-8988 (2007-08-24)
We demonstrated previously that, by suppressing cAMP levels, metabotropic glutamate receptors (mGluRs) play a crucial role in opioid receptor trafficking on GABAergic nerve terminals within gastric brainstem vagal circuits. Using whole-cell patch-clamp recordings, we aimed to correlate the influence of
Jingyi Ma et al.
Behavioural brain research, 133(1), 45-56 (2002-06-06)
The involvement of metabotropic glutamate receptor (mGluR) subtypes in the generation of hippocampal EEG (30-100 Hz) and behaviors induced by a hippocampal afterdischarge (AD) was examined in freely behaving rats. A hippocampal AD induced an increase in gamma waves (30-100
Annabel E Simms et al.
The Journal of physiology, 575(Pt 3), 727-738 (2006-07-01)
The nucleus tractus solitarii (NTS) is the first site of integration for primary baroreceptor afferents, which release glutamate to excite second-order neurones through ionotropic receptors. In vitro studies indicate that glutamate may also activate metabotropic receptors (mGluRs) to modulate the
Kirsteen N Browning et al.
The Journal of physiology, 575(Pt 3), 761-776 (2006-07-11)
We demonstrated recently that increasing the levels of cAMP allows opioids to modulate GABAergic synaptic transmission between the nucleus of the tractus solitarius (NTS) and dorsal motor nucleus of the vagus (DMV). Using a combination of electrophysiological, immunohistochemical and biochemical
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