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Merck
CN

G2043

Gö 6976

Synonym(s):

12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, Go 6976

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About This Item

Empirical Formula (Hill Notation):
C24H18N4O
CAS Number:
136194-77-9
Molecular Weight:
378.43
UNSPSC Code:
12352204
MDL number:
MFCD00236434

Key Documents

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InChI key

VWVYILCFSYNJHF-UHFFFAOYSA-N

InChI

1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)

SMILES string

Cn1c2ccccc2c3c4C(=O)NCc4c5c6ccccc6n(CCC#N)c5c13

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Biochem/physiol Actions

Gö 6976 is an inhibitor of protein kinase C (PKC) specific for α (IC50=2.3 nM) and β1 (IC50=6.2 nM) isozymes.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Nathan L Chaplin et al.
Channels (Austin, Tex.), 6(5), 385-389 (2012-08-22)
Changes in intracellular calcium regulate countless biological processes. In arterial smooth muscle, voltage-dependent L-type calcium channels are major conduits for calcium entry with the primary function being determination of arterial diameter. Similarly, changes in intracellular redox status, either discrete controlled
Sajal Chakraborti et al.
Cellular signalling, 25(2), 512-526 (2012-11-20)
In the context of cross-talk between transmembrane signaling pathways, we studied the loci within the β-adrenergic receptor/G protein/adenyl cyclase system at which PKC exerts regulatory effects of peroxynitrite (ONOO(-)) on isoproterenol stimulated adenyl cyclase activity in pulmonary artery smooth muscle
Jianwei Wang et al.
PloS one, 7(9), e45043-e45043 (2012-10-03)
Protein kinase C (PKC) is involved in gonadotrophin-induced oocyte maturation. In the present study, we investigated the role of specific PKC isoforms in the process of follicle-stimulating hormone (FSH)-induced oocyte meiotic resumption. Small antral follicles (200-300 µm in diameter) were
Hammou Oubrahim et al.
The Journal of biological chemistry, 288(4), 2805-2815 (2012-12-12)
Pasteurella multocida toxin (PMT) is a potent mitogen known to activate several signaling pathways via deamidation of a conserved glutamine residue in the α subunit of heterotrimeric G-proteins. However, the detailed mechanism behind mitogenic properties of PMT is unknown. Herein
Sung Youn Jung et al.
Experimental cell research, 319(3), 153-160 (2012-10-16)
Gö6976 is a nonglycosidic indolocarbazole compound widely used as a specific inhibitor of PKCα/β. In experiments probing for a role of PKCα in human laminin-2-integrin-mediated cell adhesion and spreading of PC12 cells, we observed unexpected enhancements of adhesion, spreading and
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