G211200
DMT-2′Fluoro-dG(ib) Phosphoramidite
Synonym(s):
DMT-2′Fluoro-dG(ib) Amidite
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About This Item
InChI
1S/C44H53FN7O8P/c1-27(2)40(53)49-43-48-39-37(41(54)50-43)47-26-51(39)42-36(45)38(60-61(58-24-12-23-46)52(28(3)4)29(5)6)35(59-42)25-57-44(30-13-10-9-11-14-30,31-15-19-33(55-7)20-16-31)32-17-21-34(56-8)22-18-32/h9-11,13-22,26-29,35-36,38,42H,12,24-25H2,1-8H3,(H2,48,49,50,53,54)/t35-,36-,38-,42-,61?/m1/s1
SMILES string
COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](F)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(NC(=O)C(C)C)=Nc34)(c5ccccc5)c6ccc(OC)cc6
InChI key
KJFUMXZZVYMQEU-AOCJBPQJSA-N
biological source
non-animal source (no BSE/TSE risk)
product line
Proligo Reagents
assay
≥99% (31P-NMR)
≥99.0% (reversed phase HPLC)
form
powder
technique(s)
oligo synthesis: suitable
impurities
≤0.3% water content (Karl Fischer)
≤0.5% P(III) Impurities 100-169ppm (31P-NMR)
≤0.5% single Impurity (reversed phase HPLC)
≤3% residual Solvent content
color
white to off-white
λ
conforms (UV/VIS Identity)
suitability
conforms to structure for H-NMR
conforms to structure for LC-MS
nucleoside profile
base: deoxyguanosine
base protecting group: isobutyryl
2' protecting group: fluoro
5' protecting group: DMT
deprotection: fast/standard
storage temp.
−20°C
Quality Level
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General description
Its key features include,
- Can be employed together with DNA or RNA phosphoramidites
- Recommended deprotection conditions are 8 hours at 55 °C using concentrated ammonia solution, or with AMA for 10 minutes at 65 °C
- Synthesis of 2′Fluoro oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 3 minutes compared to 90 seconds for DNA monomers)
- Consistent lot-to-lot high purity and performance
- Manufactured under a certified ISO 9001 quality system
Application
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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