G2653
Globulin, corticosteroid-binding from human plasma
lyophilized powder
Synonym(s):
CBG, Transcortin
biological source
human plasma
form
lyophilized powder
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... SERPINA6(866)
Biochem/physiol Actions
A 56 kDa glycosylated β-globulin present in serum that regulates the concentration of glucocorticoids and progesterone.
Packaging
Package size based on protein content
Physical form
Lyophilized from 1.25 mM sodium phosphate, pH 7.4, containing 0.05% sodium azide
Regulatory Information
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C Lindgren et al.
Acta anaesthesiologica Scandinavica, 57(4), 452-460 (2012-11-22)
Subarachnoid haemorrhage (SAH) is a life-threatening condition that may be aggravated by acute pituitary damage and cortisol insufficiency. Robust diagnostic criteria for critical illness-related corticosteroid insufficiency (CIRCI) are lacking. The aim of this study was to assess the frequency of
The steroid-binding beta-globulin of human plasma.
W Heyns
Advances in steroid biochemistry and pharmacology, 6, 59-79 (1977-01-01)
L A Hill et al.
The Journal of clinical endocrinology and metabolism, 97(11), 4260-4267 (2012-09-06)
Corticosteroid-binding globulin (CBG), encoded by SERPINA6, is the principal plasma binding protein for cortisol. Most nonsynonymous single-nucleotide polymorphisms that alter the production or function of CBG occur rarely, and their clinical significance remains obscure. Serum and DNA were obtained from
Bevin Gangadharan et al.
PloS one, 7(6), e39603-e39603 (2012-07-05)
Liver biopsy is the reference standard for assessing liver fibrosis and no reliable non-invasive diagnostic approach is available to discriminate between the intermediate stages of fibrosis. Therefore suitable serological biomarkers of liver fibrosis are urgently needed. We used proteomics to
John G Lewis et al.
Clinica chimica acta; international journal of clinical chemistry, 416, 26-30 (2012-11-28)
The predominant carrier of cortisol in circulation is corticosteroid-binding globulin (CBG) which is a non-functional member of the family of serine protease inhibitors. Corticosteroid-binding globulin possesses an exposed elastase sensitive loop and upon cleavage it adopts a "relaxed" conformation promoting
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