G2653
Globulin, corticosteroid-binding from human plasma
lyophilized powder
Synonym(s):
CBG, Transcortin
biological source
human plasma
form
lyophilized powder
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... SERPINA6(866)
Biochem/physiol Actions
A 56 kDa glycosylated β-globulin present in serum that regulates the concentration of glucocorticoids and progesterone.
Packaging
Package size based on protein content
Physical form
Lyophilized from 1.25 mM sodium phosphate, pH 7.4, containing 0.05% sodium azide
Regulatory Information
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Ellen Kanitz et al.
PloS one, 7(12), e52748-e52748 (2013-01-10)
Imbalanced maternal nutrition during gestation can cause alterations of the hypothalamic-pituitary-adrenal (HPA) system in offspring. The present study investigated the effects of maternal low- and high-protein diets during gestation in pigs on the maternal-fetal HPA regulation and expression of the
Liesbeth Knaepen et al.
PloS one, 8(2), e57608-e57608 (2013-02-26)
Early life events can significantly alter the development of the nociceptive circuit. In fact, clinical work has shown that maternal adversity, in the form of depression, and concomitant selective serotonin reuptake inhibitor (SSRI) treatment influence nociception in infants. The combined
G E Hodes et al.
Neuroscience, 222, 269-280 (2012-06-28)
Stress hormones are thought to be involved in the etiology of depression, in part, because animal models show they cause morphological damage to the brain, an effect that can be reversed by chronic antidepressant treatment. The current study examined two
Camilo Lellis-Santos et al.
Endocrinology, 153(8), 3668-3678 (2012-06-16)
The transition from gestation to lactation is characterized by a robust adaptation of maternal pancreatic β-cells. Consistent with the loss of β-cell mass, glucose-induced insulin secretion is down-regulated in the islets of early lactating dams. Extensive experimental evidence has demonstrated
J Ghose-Dastidar et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(15), 6408-6412 (1991-08-01)
Human corticosteroid binding globulin (hCBG) is a 50- to 55-kDa serum glycoprotein that binds cortisol and progesterone with high affinity. To map the steroid-binding domain and to investigate the folding pathways of hCBG, we have established an expression system based
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