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Merck
CN

G3796

Granisetron hydrochloride

≥98% (HPLC), solid

Synonym(s):

1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H24N4O· HCl
CAS Number:
107007-99-8
Molecular Weight:
348.87
NACRES:
NA.77
PubChem Substance ID:
329799917
UNSPSC Code:
12352200
MDL number:
MFCD01747034

Key Documents

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InChI

1S/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12-,13+,14-;

SMILES string

Cl.CN1[C@H]2CCC[C@@H]1C[C@@H](C2)NC(=O)c3nn(C)c4ccccc34

InChI key

QYZRTBKYBJRGJB-WQTKJZBYSA-N

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to off-white

mp

284.0-290.0 °C

solubility

H2O: >10 mg/mL

originator

Roche

storage temp.

room temp

Quality Level

100

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Biochem/physiol Actions

Granisetron hydrochloride helps to block nausea/emesis and abdominal pain in irritable bowel syndrome, that is stimulated by chemotherapy.
Granisetron hydrochloride is a serotonin 5-HT3 receptor antagonist and antiemetic.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000276010
0000276010
0000077300
0000060827
0000060826

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Alterations of colonic sensitivity and gastric dysmotility after acute cisplatin and granisetron
Martin R, et al.
Neurogastroenterology and Motility, e13499-e13499 (2018)
Mohammad-Reza Khodaie-Ardakani et al.
Journal of psychiatric research, 47(4), 472-478 (2013-02-05)
Some 5-HT3 antagonists such as ondansetron have shown beneficial effects on negative symptoms of patients with schizophrenia. We aimed to evaluate the efficacy of granisetron (another 5-HT3 antagonist) add-on therapy in the treatment of negative symptoms of patients with stable
Hea-Jeong Doh et al.
Colloids and surfaces. B, Biointerfaces, 101, 475-480 (2012-09-27)
A new lipid nanoemulsion (LNE) system containing granisetron (GRN) was developed and its in vitro permeation-enhancing effect was evaluated using Caco-2 cell monolayers. Particle size, polydispersity index (PI) and stability of the prepared GRN-loaded LNE systems were also characterized. The
Yuko Horii et al.
Neuroscience letters, 539, 32-37 (2013-02-09)
Lactobacilli provide several health benefits to mammals, including humans. We previously observed that in rats, intraduodenal injection of Lactobacillus johnsonii La1 elevated efferent gastric vagal nerve activity (efferent-GVNA), while Lactobacillus paracasei ST11 suppressed efferent-GVNA, and thereby increased or decreased food
Divya Kesters et al.
EMBO reports, 14(1), 49-56 (2012-12-01)
The 5-HT(3) receptor is a pentameric serotonin-gated ion channel, which mediates rapid excitatory neurotransmission and is the target of a therapeutically important class of anti-emetic drugs, such as granisetron. We report crystal structures of a binding protein engineered to recognize
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