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G4635

Gitoxigenin

Synonym(s):

16β-Hydroxydigitoxigenin, 3β,14,16β,21-Tetrahydroxy-20(22)-norcholenic acid lactone, 3β,14,16β-Trihydroxy-5β,20(22)-cardenolide, 5β,20(22)-Cardenolide-3β,14,16β-triol

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About This Item

Empirical Formula (Hill Notation):
C23H34O5
CAS Number:
545-26-6
Molecular Weight:
390.51
PubChem Substance ID:
24895182
UNSPSC Code:
12352200
EC Number:
208-886-2
MDL number:
MFCD00021174
Beilstein/REAXYS Number:
96483
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storage temp.

−20°C

SMILES string

[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H]([C@@H](O)C[C@]34O)C5=CC(=O)OC5)[C@@]1(C)CC[C@H](O)C2

Biochem/physiol Actions

Structure-activity relationships for 16β-substituted digitoxigenins as inhibitors of Na+/K+ ATPases.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
025F3442

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Tomonori Arao et al.
Journal of analytical toxicology, 26(4), 222-227 (2002-06-11)
Simultaneous determination of oleandrin and its three related compounds, desacetyloleandrin, oleandrigenin, and gitoxigenin in blood by using liquid chromatography-three-dimensional quadrupole mass spectrometry (LC-3DQMS) system equipped with sonic spray ionization (SSI) interface was conducted. This analyzing method was suitable for all
Miguel López-Lázaro et al.
Planta medica, 69(8), 701-704 (2003-10-08)
Recent research has shown the anticancer effects of digitalis compounds suggesting their possible use in medical oncology. Four extracts obtained from the leaves of Digitalis purpurea subsp. heywoodii have been assessed for cytotoxic activity against three human cancer cell lines
Jack T Rogers et al.
Journal of neural transmission (Vienna, Austria : 1996), 118(3), 493-507 (2011-01-12)
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD). Dopaminergic neurons exhibit elevated iron levels that can accelerate toxic SNCA fibril formation. Examinations of human post mortem brain
Jenny Felth et al.
Journal of natural products, 72(11), 1969-1974 (2009-11-10)
Cardiac glycosides have been reported to exhibit cytotoxic activity against several different cancer types, but studies against colorectal cancer are lacking. In a screening procedure aimed at identifying natural products with activity against colon cancer, several cardiac glycosides were shown
Rupali Dhara et al.
Journal of oleo science, 59(4), 169-176 (2010-03-20)
The amount and characterization of phytosterol and other minor components present in three Indian minor seed oils, mahua (Madhuca latifolia), sal (Shorea robusta) and mango kernel (Mangifera indica), have been done. Theses oils have shown commercial importance as cocoa-butter substitutes
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