G4651
Monosialoganglioside-GM2-pyrene labeled
from bovine brain, ~95%
Synonym(s):
GM2-Pyrene
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About This Item
UNSPSC Code:
12352200
MDL number:
biological source
bovine brain
assay
~95%
storage temp.
−20°C
Preparation Note
Vacuum dried
Analysis Note
Labeled GM2 gives blue fluorescence with activation at 366 nm
Other Notes
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage. For classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Lysogangliosides: synthesis and use in preparing labeled gangliosides.
G Schwarzmann et al.
Methods in enzymology, 138, 319-341 (1987-01-01)
S Sonnino et al.
Chemistry and physics of lipids, 42(1-3), 3-26 (1986-12-15)
A report is given of recent progress in the methodology for isolation of gangliosides from natural sources, for the preparation of molecular species of gangliosides homogeneous in both the oligosaccharide and ceramide portions of the molecule, for chemical manipulation and
Meng Guo et al.
Biochemical and biophysical research communications, 516(3), 914-920 (2019-07-06)
The Ig superfamily member V-domain Ig-containing suppressor of T-cell activation (VISTA) is a negative regulator with broad-spectrum activities and has reported that blockade of VISTA or combination with other negative checkpoint receptors sufficiently break tumor tolerance. However, it remains unclear
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