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Merck
CN

G4651

Sigma-Aldrich

Monosialoganglioside-GM2-pyrene labeled

from bovine brain, ~95%

Synonym(s):

GM2-Pyrene

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About This Item

MDL number:
UNSPSC Code:
12352200
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biological source

bovine brain

Assay

~95%

storage temp.

−20°C

Preparation Note

Vacuum dried

Analysis Note

Labeled GM2 gives blue fluorescence with activation at 366 nm

Other Notes

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage. For classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Lysogangliosides: synthesis and use in preparing labeled gangliosides.
G Schwarzmann et al.
Methods in enzymology, 138, 319-341 (1987-01-01)
S Sonnino et al.
Chemistry and physics of lipids, 42(1-3), 3-26 (1986-12-15)
A report is given of recent progress in the methodology for isolation of gangliosides from natural sources, for the preparation of molecular species of gangliosides homogeneous in both the oligosaccharide and ceramide portions of the molecule, for chemical manipulation and
Meng Guo et al.
Biochemical and biophysical research communications, 516(3), 914-920 (2019-07-06)
The Ig superfamily member V-domain Ig-containing suppressor of T-cell activation (VISTA) is a negative regulator with broad-spectrum activities and has reported that blockade of VISTA or combination with other negative checkpoint receptors sufficiently break tumor tolerance. However, it remains unclear

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