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Merck
CN

G5291

L-α-Glycerophosphorylcholine

≥98%, powder

Synonym(s):

Choline Glycerophosphate, Choline alphoscerate

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About This Item

Empirical Formula (Hill Notation):
C8H20NO6P
Molecular Weight:
257.22
NACRES:
NA.83
PubChem Substance ID:
24895204
UNSPSC Code:
12352204
EC Number:
248-962-2
MDL number:
MFCD00063544

Key Documents

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Product Name

L-α-Glycerophosphorylcholine, from soybean, ≥98%, powder

InChI

1S/C8H21NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3,(H,12,13)

InChI key

XGPKIOAEPQZUED-UHFFFAOYSA-N

SMILES string

C[N](C)(C)CCOP(O)(=O)OC[C@@H](O)CO

biological source

soybean

assay

≥98%

form

powder

solubility

water: 50 mg/mL, clear, colorless to very faintly yellow

storage temp.

−20°C

Application

L-α-Glycerophosphorylcholine has been used to rescue choline auxotrophy. It has also been used for the synthesis of glycerophospholipids.

Biochem/physiol Actions

Increases inositol phosphate formation.

General description

L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCD5882
BCCD4176
129K1796
129K1795
039K1070

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Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial
Moreno MDJM
Clinical Therapeutics, 25(1), 178-193 (2003)
Alzheimer's Disease: Current Research In Early Diagnosis (1990)
Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation?
Parnetti L, et al.
Journal of the Neurological Sciences, 257(1-2), 264-269 (2007)
Overproduction of Phospholipids by the Kennedy Pathway Leads to Hypervirulence in Candida albicans
Tams RN, et al.
Frontiers in Microbiology, 10 (2019)
High-Throughput Plasma Lipidomics: Detailed Mapping of the Associations with Cardiometabolic Risk Factors
Huynh K, et al.
Cell Chemical Biology, 26(1), 71-84 (2019)

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