G5650
Grb2 SH2-domain Protein A fusion protein
≥90% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
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About This Item
UNSPSC Code:
12352204
MDL number:
Form:
lyophilized powder
Assay:
≥90% (SDS-PAGE)
Recombinant:
expressed in E. coli
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
lyophilized powder
composition
Protein, 3-5%
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... GRB2(2885)
Biochem/physiol Actions
A key protein in signal transduction, Grb2 transfers the signal from tyrosine kinases such as epidermal growth factor (EGF) receptor to the small G protein Ras. GRB2 contains an SH2 (Src homology 2) domain which enables binding to tyrosine-phosphorylated receptors. The fusion protein enables detection and purification of tyrosine-phosphorylated proteins (i.e., tyrosine-phosphorylated EGF receptor), utilizing the affinity of protein A for the Fc domain of IgG.
Packaging
Package size based on protein content
Physical form
Contains potassium phosphate and sodium chloride
Other Notes
A 37 kDa fusion protein containing the SH2 domain of mouse Grb2 (amino acids 50-161) fused to protein A.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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J P Olivier et al.
Cell, 73(1), 179-191 (1993-04-09)
A Drosophila gene (drk) encodes a widely expressed protein with a single SH2 domain and two flanking SH3 domains, which is homologous to the Sem-5 protein of C. elegans and mammalian GRB2. Genetic analysis suggests that drk function is essential
B Margolis
Progress in biophysics and molecular biology, 62(3), 223-244 (1994-01-01)
The cloning of SH2 domain proteins based on their binding to growth factor receptors is a powerful technique to elucidate new signaling pathways. In some cases the function of these proteins has been quickly ascertained while in others the answers
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