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Merck
CN

G5889

L-Glutamic acid monosodium salt hydrate

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

Synonym(s):

(S)-2-Aminopentanedioic acid, L-Glutamic acid monosodium salt, Glu, MSG, Monosodium glutamate

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About This Item

Empirical Formula (Hill Notation):
C5H8NNaO4 · xH2O
CAS Number:
142-47-2
Molecular Weight:
169.11 (anhydrous basis)
EC Number:
205-538-1
MDL number:
MFCD00013074
UNSPSC Code:
12352209
PubChem Substance ID:
24895237
NACRES:
NA.75

Key Documents

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product line

BioReagent

Quality Level

200

Assay

≥99%

form

powder

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

color

white to off-white

mp

163 °C

SMILES string

[NaH].NC(CCC(=O)O)C(=O)O.O

InChI

1S/C5H9NO4.Na.H2O.H/c6-3(5(9)10)1-2-4(7)8;;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2;

InChI key

JYDGDQPVBSBYRT-UHFFFAOYSA-N

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General description

L-Glutamic acid/monosodium glutamate (MSG) is the sodium salt of glutamic acid. It is a commonly used food additive.

Application

L-Glutamic acid monosodium salt hydrate has been used:
  • to prepare glutamate stock solution in HEPES-buffered saline (HBS) for glutamate perfusions
  • as a component in YNG (yeast nitrogen base glutamate) medium
  • used to treat HT22 hippocampal cells to study its effects on cell viability and to examine the expression of molecules related to apoptotic cell death
  • as a component of fresh media to culture neurons and to assess glutamate uptake

Biochem/physiol Actions

Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.
Monosodium glutamate (MSG) is a food additive and an environmental agent, that can affect inflammation.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000485509
0000485509
0000466819
0000466819
0000444314

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Neuroprotective effects of 2, 3, 5, 4?-tetrahydoxystilbene-2-O-beta-D-glucoside from Polygonum multiflorum against glutamate-induced oxidative toxicity in HT22 cells
Lee S Y, et al.
Journal of Ethnopharmacology, 195, 64-70 (2017)
Neuroprotective actions of noradrenaline: effects on glutathione synthesis and activation of peroxisome proliferator activated receptor delta
Madrigal J LM, et al.
Journal of Neurochemistry, 103(5), 2092-2101 (2007)
Microfluidic local perfusion chambers for the visualization and manipulation of synapses
Taylor A M, et al.
Neuron, 66(1), 57-68 (2010)
Food and Toxicologic Pathology: An Overview
Haschek and Rousseaux's Handbook of Toxicologic Pathology, 1051-1076 (2013)
Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia
Nakanishi Y, et al.
Journal of Autoimmunity, 30(1-2), 42-50 (2008)
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