G6004
Glutathione Reductase from wheat germ
Type II, ≥0.08 units/mg protein
Synonym(s):
GR, NAD(P)H: oxidized-glutathione oxidoreductase
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About This Item
CAS Number:
UNSPSC Code:
12352204
EC Number:
232-608-9
MDL number:
type
Type II
specific activity
≥0.08 units/mg protein
mol wt
118 kDa
storage temp.
−20°C
Biochem/physiol Actions
A crucial flavoenzyme in the antioxidant defense system. Reduced glutathione (GSH) is used by glutathione peroxidase to detoxify hydrogen peroxide and in the process is converted to oxidized glutathione (GSSG). The GSSG is then recycled back to GSH by glutathione reductase (GR) using NADPH that is then converted to NADP+. The regenerated GSH is then available to detoxify more hydrogen peroxide. The enzyme uses FAD as a cofactor. GR and glutathione peroxidase may inhibit lipid peroxidation by functioning as antioxidant enzymes in sperm. Glutathione reductase shares a structural motif with a number of other proteins including aspartyl proteases, citrate synthase, EF hands, hemoglobins, lipocalins, and α/β hydrolases. GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems.
Analysis Note
Crude
Other Notes
One unit will reduce 1.0 μmole of oxidized glutathione per min at pH 7.6 at 25 °C. (Protein determined by biuret).
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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