G6011
Gly-Pro-Gly-Gly
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C11H18N4O5
CAS Number:
Molecular Weight:
286.28
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C11H18N4O5/c12-4-9(17)15-3-1-2-7(15)11(20)14-5-8(16)13-6-10(18)19/h7H,1-6,12H2,(H,13,16)(H,14,20)(H,18,19)
SMILES string
NCC(=O)N1CCCC1C(=O)NCC(=O)NCC(O)=O
InChI key
PEZMQPADLFXCJJ-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
technique(s)
NMR: suitable
storage temp.
−20°C
Biochem/physiol Actions
Inhibitor of dipeptidyl peptidase IV. Inhibits entry of HIV-1 or HIV-2 into T lymphoblastoid and monocytoid cell lines.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Abil E Aliev et al.
The journal of physical chemistry. B, 114(38), 12358-12375 (2010-09-10)
Experimental NMR verification of MD simulations using 12 different force fields (AMBER, CHARMM, GROMOS, and OPLS-AA) and 5 different water models has been undertaken to identify reliable MD protocols for structure and dynamics elucidations of small open chain peptides containing
I P Ashmarin et al.
Biochemistry. Biokhimiia, 63(2), 119-124 (1998-06-02)
Our own data and data from the literature on the regulatory role of the simplest proline-containing peptides GP, PG, PGP, GPGG, and cyclic-PG are summarized. These peptides are involved in homeostasis of gastric mucosa and the anticoagulant and fibrinolytic potential
[Effect of simple proline-containing peptides on the functional activity of the anticoagulant system and primary homeostasis].
I P Ashmarin et al.
Biulleten' eksperimental'noi biologii i meditsiny, 125(5), 496-499 (1998-06-30)
C Callebaut et al.
Science (New York, N.Y.), 262(5142), 2045-2050 (1993-12-24)
The CD4 molecule is essential for binding HIV particles, but is not sufficient for efficient viral entry and infection. The cofactor was shown to be dipeptidyl peptidase IV (DPP IV), also known as CD26. This serine protease cleaves its substrates
V E Pastorova et al.
Izvestiia Akademii nauk. Seriia biologicheskaia, (3)(3), 390-394 (1998-06-30)
Anticoagulant, fibrinolytic, and fibrin-depolymerization effects were revealed during in vitro study of five proline-containing peptides (Gly-Pro, Trp-Pro, Pro-Gly, Gly-Pro-Gly-Gly, and Pro-Gly-Pro) in the concentration range 10(-9) to 10(-1) mg/ml. Intravenous injection of Trp-Pro and Pro-Gly into white rats at 250
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