G6251
β-Glycerophosphate disodium salt hydrate
≤0.20% L-α-isomer
Synonym(s):
BGP, Glycerol 2-phosphate disodium salt hydrate
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About This Item
Linear Formula:
(HOCH2)2CHOP(O)(ONa)2 · xH2O
CAS Number:
Molecular Weight:
216.04 (anhydrous basis)
UNSPSC Code:
12352202
PubChem Substance ID:
EC Number:
212-464-3
MDL number:
InChI key
ROPZSVKNEIIIDE-UHFFFAOYSA-L
InChI
1S/C3H9O6P.2Na.H2O/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;;1H2/q;2*+1;/p-2
SMILES string
O.[Na+].[Na+].OCC(CO)OP([O-])([O-])=O
impurities
≤0.20% L-α-isomer
mp
102-104 °C (lit.)
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Application
β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression.
Initiates differentiation of bone-marrow-derived stem cells embedded in a natural collagen/chitosan gel designed for tissue engineering.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Buffer B70
Cold Spring Harbor Protocols, 2009, 11970-11970 (2009)
Buffer B70 (RNase-free)
Cold Spring Harbor Protocols, 2009, 11977-11977 (2009)
Limin Wang et al.
Biomaterials, 31(14), 3976-3985 (2010-02-23)
Chitosan and collagen type I are naturally derived materials used as cell carriers because of their ability to mimic the extracellular environment and direct cell function. In this study beta-glycerophosphate (beta-GP), an osteogenic medium supplement and a weak base, was
Cyril Boyault et al.
Genes & development, 21(17), 2172-2181 (2007-09-06)
A cellular defense mechanism counteracts the deleterious effects of misfolded protein accumulation by eliciting a stress response. The cytoplasmic deacetylase HDAC6 (histone deacetylase 6) was previously shown to be a key element in this response by coordinating the clearance of
Lucas R Brun et al.
SpringerPlus, 3, 676-676 (2014-12-19)
The aim of this study was to evaluate the effect of strontium ranelate (SrR) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of SrR in bisphosphonate-naïve patients (BP-naïve) compared to patients previously
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