recombinant human GRP1 (general receptor for phosphoinositides-1).

Monoclonal Anti-GRP1 antibody produced in mouse is suitable for immunocytochemistry, indirect ELISA and microarray. It is also suitable for western blot analysis at a working concentration of 2-4μg/mL using whole extract of cultured human NRK (normal rat kidney) cells.

GRP1 gene encodes a protein belonging to the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. The members of this family contain an N-terminal coiled-coil motif that is involved in homodimerization, a central Sec7 domain with guanine-nucleotide exchange protein (GEP) activity, and a C-terminal pleckstrin homology (PH) domain that interacts with phospholipids and facilitates association of PSCDs with membranes. This protein is responsible for the control of Golgi structure and function via the activation of ARF1 on Golgi membrane. It is also involved in the regulation of ARF6 functions.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.