G7657
Anti-GABA Transporter GAT-2 antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
contains
0.02% sodium azide, 1% bovine serum albumin
species reactivity
rat
technique(s)
immunohistochemistry: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
rat ... Slc6a13(171163)
Immunogen
synthetic peptide corresponding to the C-terminal domain (amino acids 594-602) of rat GAT-2.
Application
Anti-GABA Transporter GAT-2 antibody produced in rabbit is suitable for immunohistochemistry.
Biochem/physiol Actions
GAT-2 is a transporter for the selective uptake of γ-Aminobutyric acid (GABA). It belongs to a family of Na+ and Cl- co-dependent transporters, which include GAT-1, GAT-3 and BGT-1 transporters. These transporters have a molar mass of 67kDa each and contain 12 transmembrane regions. GABA is the major inhibitory neurotransmitter in the CNS and a neuromodulator in certain peripheral tissues.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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B I Kanner
The Journal of experimental biology, 196, 237-249 (1994-11-01)
The removal of neurotransmitters by their transporters--located in the plasma membranes of nerve terminals and glial cells--plays an important role in the termination of synaptic transmission. In the last 3 years, many neurotransmitter transporters have been cloned. Structurally and functionally
L A Borden
Neurochemistry international, 29(4), 335-356 (1996-10-01)
gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. GABA is cleared from the synaptic cleft by specific, high-affinity, sodium- and chloride-dependent transporters, which are thought to be located on presynaptic terminals and surrounding glial cells. While
gamma-Aminobutyric acid outside the mammalian brain.
S L Erdö et al.
Journal of neurochemistry, 54(2), 363-372 (1990-02-01)
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