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Merck
CN

G7897

Sigma-Aldrich

Granuliberin R

≥97% (HPLC)

Synonym(s):

Phe-Gly-Phe-Leu-Pro-Ile-Tyr-Arg-Arg-Pro-Ala-Ser-NH2

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About This Item

Empirical Formula (Hill Notation):
C69H103N19O14
CAS Number:
64704-41-2
Molecular Weight:
1422.68
MDL number:
MFCD00080191
UNSPSC Code:
12352200
PubChem Substance ID:
24895328

Key Documents

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Assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C1CCCN1C(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC(=O)CNC(=O)C(N)Cc3ccccc3)C(=O)NC(Cc4ccc(O)cc4)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)N5CCCC5C(=O)NC(C)C(=O)NC(CO)C(N)=O

InChI

1S/C69H103N19O14/c1-6-40(4)56(86-64(99)54-24-16-32-88(54)67(102)51(33-39(2)3)84-61(96)49(35-43-19-11-8-12-20-43)80-55(91)37-78-59(94)46(70)34-42-17-9-7-10-18-42)65(100)83-50(36-44-25-27-45(90)28-26-44)62(97)81-47(21-13-29-76-68(72)73)60(95)82-48(22-14-30-77-69(74)75)66(101)87-31-15-23-53(87)63(98)79-41(5)58(93)85-52(38-89)57(71)92/h7-12,17-20,25-28,39-41,46-54,56,89-90H,6,13-16,21-24,29-38,70H2,1-5H3,(H2,71,92)(H,78,94)(H,79,98)(H,80,91)(H,81,97)(H,82,95)(H,83,100)(H,84,96)(H,85,93)(H,86,99)(H4,72,73,76)(H4,74,75,77)

InChI key

IQNSWGKGZHMSIZ-UHFFFAOYSA-N

Biochem/physiol Actions

Mast cell degranulating peptide found in the skin of the frog, Rana rugosa.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
088H0031
018H0813
079F06652

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Synthesis of granuliberin-R and various fragment peptides and their histamine-releasing activities.
C Kitada et al.
Chemical & pharmaceutical bulletin, 28(3), 887-892 (1980-03-01)
A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin.
T Nakajima et al.
Chemical & pharmaceutical bulletin, 25(9), 2464-2465 (1977-09-01)
Marcin Kozakiewicz et al.
Cellular & molecular biology letters, 8(3), 727-734 (2003-09-02)
To assess the effect of substances inducing mast cell degranulation (substance P and granuliberin R) on the mitotic indices of the gingiva stratified epithelium, basal cells from rats were studied in vivo. Seventy Lewis male rats were used in the
J Lechago et al.
Neuroscience, 12(1), 329-337 (1984-05-01)
The histamine-releasing peptide "granuliberin", originally isolated from the skin of Rana rugosa, was localized by immunofluorescence within nerve cell bodies and fibers in the brain of Rana pipiens. The granuliberin-positive neurons were characterized ultrastructurally by electron microscopic observation of ultrathin

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