G8041
Galanin-Like Peptide Fragment 1-60 porcine trifluoroacetate salt
≥95% (HPLC), solid
Sign Into View Organizational & Contract Pricing
About This Item
Empirical Formula (Hill Notation):
C281H443N81O78
CAS Number:
Molecular Weight:
6204.02
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32
Assay
≥95% (HPLC)
form
solid
UniProt accession no.
storage temp.
−20°C
Gene Information
pig ... GALP(396772)
Amino Acid Sequence
Ala-Pro-Val-His-Arg-Gly-Arg-Gly-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-His- Pro-Pro-Ser-Arg-Ala-Glu-Gly-Gly-Gly-Lys-Gly-Lys-Thr-Ala-Leu-Gly-Ile-Leu-Asp-Leu-Trp-Lys-Ala-Ile-Asp-Gly-Leu-Pro-Tyr-Pro-Gln-Ser-Gln-Leu-Ala-Ser
General description
Galanin-like peptide (GALP) is a GALR2 (galanin receptor)-binding neuropeptide, which is produced by pig hypothalamus. This peptide is produced as 120-residue GALP precursor protein, and is processed to a 60-residue peptide, with a non-amidated C-terminal.
Biochem/physiol Actions
Endogenous ligand that preferentially binds to the GalR2 galanin receptor.
GALP-(1–60) peptide binds with high affinity to galanin receptor (GALR2). This peptide is thought to play a role in mediating the actions of leptin, a satiety hormone. It is a potent vasoactive peptide and is thought to be involved in inflammatory responses.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
新产品
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Sabine M Schmidhuber et al.
The Journal of investigative dermatology, 127(3), 716-721 (2006-10-07)
The cutaneous vasculature plays a key role in the pathophysiology of inflammatory skin diseases. The vascular activity is under the control of the peripheral nervous system that includes locally released neuropeptides. Recently, we detected receptors for the neuropeptide galanin in
J A Larm et al.
Neuroendocrinology, 72(2), 67-71 (2000-09-06)
Galanin-like peptide (GALP) is a novel 60-amino acid neuropeptide, isolated from porcine hypothalamus and subsequently identified in rats and humans, which has reported selectivity for the Gal-R2 galanin receptor [Ohtaki T et al: J Biol Chem 1999; 274: 37041-37045]. In
Matthew J Cunningham et al.
Endocrinology, 143(3), 755-763 (2002-02-28)
Galanin-like peptide (GALP) is a newly discovered hypothalamic neuropeptide, which is regulated by leptin and implicated in the regulation of GnRH secretion in the rodent. We searched the human genome database and determined that the human GALP gene comprises six
T Ohtaki et al.
The Journal of biological chemistry, 274(52), 37041-37045 (1999-12-22)
Galanin is a widely distributed neuropeptide with a variety of physiological functions. Three galanin receptor subtypes, GALR1, GALR2, and GALR3, have been reported. We isolated a novel galanin-like peptide (GALP) from porcine hypothalamus by observing its activity for increasing [(35)S]GTPgammaS
Christina Springstead Scanlon et al.
Nature communications, 6, 6885-6885 (2015-04-29)
Perineural invasion (PNI) is an indicator of poor survival in multiple cancers. Unfortunately, there is no targeted treatment for PNI since the molecular mechanisms are largely unknown. PNI is an active process, suggesting that cancer cells communicate with nerves. However
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service