G9398
Asialoganglioside-GM2 from bovine brain
~95%, lyophilized powder
Synonym(s):
GA2 Ganglioside, Gangliotriosyl ceramide
General description
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
Biochem/physiol Actions
Degraded form of Asialoganglioside-GM1 ganglioside.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Annelies Coddens et al.
PloS one, 6(9), e23309-e23309 (2011-09-29)
Enterotoxigenic F4-fimbriated Escherichia coli is associated with diarrheal disease in neonatal and postweaning pigs. The F4 fimbriae mediate attachment of the bacteria to the pig intestinal epithelium, enabling an efficient delivery of diarrhea-inducing enterotoxins to the target epithelial cells. There
K Tadano-Aritomi et al.
Glycoconjugate journal, 13(2), 285-293 (1996-04-01)
A novel mono-sulfated glycosphingolipid based on the gangliotriaose core structure was isolated from rat kidney. The isolation procedure involved extraction of lipids with chloroform/methanol, mild alkaline methanolysis, column chromatographies with anion exchangers and silica beads. The structure was characterized by
H Usui et al.
Acta medica Okayama, 48(6), 305-309 (1994-12-01)
Immunotoxins composed of monoclonal antibodies (mAbs) and various toxins have been developed for the treatment of malignancies. We investigated the efficacy of three ricin toxin A-chain (RTA)-containing immunotoxins (ITs) conjugated from mAbs which recognize glycolipid asialo-GM2 and glycoprotein H-2d. These
Christian H Schweppe et al.
Journal of lipid research, 51(8), 2282-2294 (2010-05-07)
Shiga toxin (Stx)-producing Escherichia coli are the leading cause of hemorrhagic colitis and life-threatening extraintestinal complications in humans. Stx1 and Stx2 are transferred by yet to be delineated mechanisms from the intestine to the circulation where they injure microvascular endothelial
K Watanabe et al.
European journal of biochemistry, 230(3), 971-976 (1995-06-15)
Glycosphingolipids were extracted from the brain of house musk shrew (Suncus murinus). Neutral glycosphingolipids were purified by QAE-Sephadex column chromatography followed by high-performance liquid chromatography using an Iatrobeads column. Purified glycosphingolipids were identified by high-performance thin-layer chromatography, carbohydrate analysis, fast-atom
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