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G9423

GYPGQV trifluoroacetate salt

≥98% (HPLC), powder

Synonym(s):

Gly-Tyr-Pro-Gly-Gln-Val trifluoroacetate salt, Glycyl-L-tyrosyl-L-prolyl-glycyl-L-glutaminyl-L-valine trifluoroacetate salt, PAR 4 (1-6)

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About This Item

Empirical Formula (Hill Notation):
C28H41N7O9
Molecular Weight:
619.67
NACRES:
NA.77
PubChem Substance ID:
329799989
UNSPSC Code:
12352200
MDL number:
MFCD18782242
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assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

H2O: >2 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CN)C(O)=O

InChI

1S/C28H41N7O9.C2HF3O2/c1-15(2)24(28(43)44)34-25(40)18(9-10-21(30)37)32-23(39)14-31-26(41)20-4-3-11-35(20)27(42)19(33-22(38)13-29)12-16-5-7-17(36)8-6-16;3-2(4,5)1(6)7/h5-8,15,18-20,24,36H,3-4,9-14,29H2,1-2H3,(H2,30,37)(H,31,41)(H,32,39)(H,33,38)(H,34,40)(H,43,44);(H,6,7)/t18-,19-,20-,24-;/m0./s1

InChI key

QKXFYYGUAIKLHO-XESNDDQGSA-N

Application

GYPGQV trifluoroacetate salt has been used as a protease-activated receptor 4 (PAR4) peptide agonist to test its effect on guinea-pig lower esophageal sphincter.

Biochem/physiol Actions

GYPGQV peptide displays comparatively lower binding towards annexin than SFLLRN. It induces human platelet aggregation but not to the extent of GYPGKF peptide. GYPGQV is a weaker agonist of protease-activated receptor 4 (PAR4) signaling compared to AYPGKF.
Protease-activated receptor-4 (PAR4) agonist

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
031M4742V

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Soochong Kim et al.
Blood, 99(10), 3629-3636 (2002-05-03)
Thrombin is an important agonist for platelet activation and plays a major role in hemostasis and thrombosis. Thrombin activates platelets mainly through protease-activated receptor 1 (PAR1), PAR4, and glycoprotein Ib. Because adenosine diphosphate and thromboxane A(2) have been shown to
R T Dorsam et al.
Journal of thrombosis and haemostasis : JTH, 2(5), 804-812 (2004-04-22)
The activated platelet surface serves as an integral part of the prothrombinase complex upon activation by potent platelet agonists such as thrombin and collagen. We determined the receptor specificity through which thrombin was enhancing collagen-induced thrombin generation. Whereas SFLLRN or
Shih-Che Huang
Regulatory peptides, 142(1-2), 37-43 (2007-03-06)
Protease-activated receptor-1 (PAR1), PAR2 and PAR4 activation can alter the gastrointestinal motility. To investigate effects mediated by PARs in the lower esophageal sphincter, we measured contraction or relaxation of transverse strips from the guinea-pig lower esophageal sphincter caused by PAR1
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