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Merck
CN

G9502

Guanylyl(3′→5′)uridine ammonium salt

Synonym(s):

GpU

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About This Item

Linear Formula:
C19H24N7O13P · NH3
CAS Number:
41547-83-5
Molecular Weight:
606.44
UNSPSC Code:
41106305
PubChem Substance ID:
24895373
MDL number:
MFCD00058648

Key Documents

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form

solid

storage temp.

−20°C

SMILES string

N.NC1=NC(=O)c2ncn(C3OC(CO)C(OP(O)(=O)OCC4OC(C(O)C4O)N5C=CC(=O)NC5=O)C3O)c2N1

InChI

1S/C19H24N7O13P.H3N/c20-18-23-14-9(15(32)24-18)21-5-26(14)17-12(31)13(6(3-27)37-17)39-40(34,35)36-4-7-10(29)11(30)16(38-7)25-2-1-8(28)22-19(25)33;/h1-2,5-7,10-13,16-17,27,29-31H,3-4H2,(H,34,35)(H,22,28,33)(H3,20,23,24,32);1H3

InChI key

BBBUJXLTQPKTLN-UHFFFAOYSA-N

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
031F4012

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Hande Boyaci et al.
Nature, 565(7739), 382-385 (2019-01-11)
A key regulated step of transcription is promoter melting by RNA polymerase (RNAP) to form the open promoter complex1-3. To generate the open complex, the conserved catalytic core of the RNAP combines with initiation factors to locate promoter DNA, unwind
James Chen et al.
Molecular cell, 68(2), 388-397 (2017-10-11)
Noncoding RNAs (ncRNAs) regulate gene expression in all organisms. Bacterial 6S RNAs globally regulate transcription by binding RNA polymerase (RNAP) holoenzyme and competing with promoter DNA. Escherichia coli (Eco) 6S RNA interacts specifically with the housekeeping σ
Alena Kroupova et al.
Nucleic acids research, 47(2), 1030-1042 (2018-11-22)
Non-templated 3'-uridylation of RNAs has emerged as an important mechanism for regulating the processing, stability and biological function of eukaryotic transcripts. In Drosophila, oligouridine tailing by the terminal uridylyl transferase (TUTase) Tailor of numerous RNAs induces their degradation by the
Elizabeth Davis et al.
Nucleic acids research, 43(1), 433-445 (2014-12-17)
Escherichia coli has served as the archetypal organism on which the overwhelming majority of biochemical characterizations of bacterial RNA polymerase (RNAP) have been focused; the properties of E. coli RNAP have been accepted as generally representative for all bacterial RNAPs.

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