GPHOS1
GlycoProfile™ FLAG® –Phosphine conjugate
Synonym(s):
N-[4-Carbomethoxy-3-(diphenylphosphino)benzoyl]-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys
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About This Item
Empirical Formula (Hill Notation):
C62H75N10O23P
Molecular Weight:
1359.29
UNSPSC Code:
12352200
shipped in
dry ice
storage temp.
−20°C
Application
This reagent incorporates a reactive phosphine conjugated with the FLAG tag sequence for interaction with metabolically incorporated azido-sugars. It can enable detection and/or enrichment using a broad range of FLAG reagents that are conjugated to dye molecules or solid supports from Sigma-Aldrich. The FLAG system allows for highly specific interactions, avoiding off-target detection and unwanted contamination. This system also avoids undesirable toxic effects that may result in inaccurate representation of the glycoproteome.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
GlycoProfile is a trademark of Sigma-Aldrich Co. LLC
Regulatory Information
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Jennifer A Prescher et al.
Nature, 430(7002), 873-877 (2004-08-20)
Cell surfaces are endowed with biological functionality designed to mediate extracellular communication. The cell-surface repertoire can be expanded to include abiotic functionality through the biosynthetic introduction of unnatural sugars into cellular glycans, a process termed metabolic oligosaccharide engineering. This technique
C R Bertozzi et al.
Science (New York, N.Y.), 291(5512), 2357-2364 (2001-03-28)
Chemical tools have proven indispensable for studies in glycobiology. Synthetic oligosaccharides and glycoconjugates provide materials for correlating structure with function. Synthetic mimics of the complex assemblies found on cell surfaces can modulate cellular interactions and are under development as therapeutic
E Saxon et al.
Science (New York, N.Y.), 287(5460), 2007-2010 (2000-03-17)
Selective chemical reactions enacted within a cellular environment can be powerful tools for elucidating biological processes or engineering novel interactions. A chemical transformation that permits the selective formation of covalent adducts among richly functionalized biopolymers within a cellular context is
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