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Merck
CN

GW10842F

Sigma-Aldrich

Anti-Rev antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ART/TRS, Anti-Anti-Repression transactivator protein, Anti-Protein Rev

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About This Item

MDL number:
MFCD00212000
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

viral

manufacturer/tradename

Genway 15-288-10842F

technique(s)

western blot: suitable

NCBI accession no.

AAK08487.1

UniProt accession no.

P04618

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human immunodeficiency virus 1 ... Rev(155908)

General description

Rev is a regulatory protein of human immunodeficiency virus type 1. It consists of a hydrophobic core, which is formed by binding to another REV molecule and arginine-rich motifs (ARMs).

Immunogen

Immunogen Sequence: GI # 12831140, sequence 1-116
Recombinant Rev protein (HIV-1 vector pNL4-3)

Application

Anti-Rev antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.

Biochem/physiol Actions

Rev is involved in the stabilization and transport of the viral mRNA. It is involved in the up-regulation of the gag- and env-producing mRNAs via cis-acting element in the env region of HIV-1, named rev responsive element. It increases the stability of the unspliced viral mRNA and promotes the transport of the viral mRNA having the rev-responsive element from the nucleus to the cytoplasm.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
039K1755
029K1671
029K1673
029K1672

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B K Felber et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(5), 1495-1499 (1989-03-01)
rev (trs/art) is an essential human immunodeficiency virus type 1 (HIV-1) regulatory protein. rev increases the levels of the gag- and env-producing mRNAs via a cis-acting element in the env region of HIV-1, named rev-responsive element. Our results show that
Xianyang Fang et al.
Cell, 155(3), 594-605 (2013-11-19)
Nuclear export of unspliced and singly spliced viral mRNA is a critical step in the HIV life cycle. The structural basis by which the virus selects its own mRNA among more abundant host cellular RNAs for export has been a

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